Seroatlas · Human Serome Atlas

TXNDC15

Thioredoxin domain-containing protein 15

Also known as: 2310047H23Rik, C5orf14, FLJ22625, TXD15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96J42
Gene
TXNDC15
Ensembl
ENSG00000113621
Chromosome
5
Canonical length
360 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q96J42|TXNDC15
     1  MVPAAGRRPP RVMRLLGWWQ VLLWVLGLPV RGVEVAEESG RLWSEEQPAH PLQVGAVYLG
    61  EEELLHDPMG QDRAAEEANA VLGLDTQGDH MVMLSVIPGE AEDKVSSEPS GVTCGAGGAE
   121  DSRCNVRESL FSLDGAGAHF PDREEEYYTE PEVAESDAAP TEDSNNTESL KSPKVNCEER
   181  NITGLENFTL KILNMSQDLM DFLNPNGSDC TLVLFYTPWC RFSASLAPHF NSLPRAFPAL
   241  HFLALDASQH SSLSTRFGTV AVPNILLFQG AKPMARFNHT DRTLETLKIF IFNQTGIEAK
   301  KNVVVTQADQ IGPLPSTLIK SVDWLLVFSL FFLISFIMYA TIRTESIRWL IPGQEQEHVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXNDC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 89 nTPM
  • thyroid gland: 56 nTPM
  • blood vessel: 54 nTPM
  • epididymis: 53 nTPM
  • pituitary gland: 48 nTPM
  • pancreas: 47 nTPM

Single-cell type

  • plasma cells: 284 nCPM
  • decidual stromal cells: 120 nCPM
  • retinal horizontal cells: 118 nCPM
  • retinal pigment epithelial cells: 85 nCPM
  • differentiating spermatogonia: 84 nCPM
  • epididymal principal cells: 81 nCPM

Immune cell

  • classical monocyte: 35 nTPM
  • non-classical monocyte: 34 nTPM
  • intermediate monocyte: 34 nTPM
  • basophil: 33 nTPM
  • MAIT T-cell: 33 nTPM
  • memory CD8 T-cell: 33 nTPM

Brain region

  • choroid plexus: 84 nTPM
  • medulla oblongata: 56 nTPM
  • hypothalamus: 52 nTPM
  • white matter: 51 nTPM
  • basal ganglia: 49 nTPM
  • cerebellum: 49 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TXNDC15.

Disease | AllUniProt

Conditions TXNDC15 is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.01
gnomAD missense Z
0.56
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXNDC15 as an antibody target. Whether an autoantibody or antibody against TXNDC15 could matter depends on whether native TXNDC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXNDC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXNDC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TXNDC15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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