TTMP
TPA-induced transmembrane protein
Also known as: C3orf52, FLJ23186, TTMP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5BVD1
- Gene
- TTMP
- Ensembl
- ENSG00000114529
- Chromosome
- 3
- Canonical length
- 217 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Located in plasma membrane. Implicated in hypotrichosis 15. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
217 residues, UniProt reviewed canonical sequence.
>Q5BVD1|TTMP
1 MDLAQPSQPV DELELSVLER QPEENTPLNG ADKVFPSLDE EVPPAEANKE SPWSSCNKNV
61 VGRCKLWMII TSIFLGVITV IIIGLCLAAV TYVDEDENEI LELSSNKTFF IMLKIPEECV
121 AEEELPHLLT ERLTDVYSTS PSLGRYFTSV EIVDFSGENA TVTYDLQFGV PSDDENFMKY
181 MMSEELVLGI LLQDFRDQNI PGCESLGLDP TSLLLYELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TTMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- skin: 26 nTPM
- pancreas: 17 nTPM
- stomach: 13 nTPM
- rectum: 13 nTPM
- thyroid gland: 7.4 nTPM
- colon: 7.1 nTPM
Single-cell type
- urothelial cells: 416 nCPM
- ocular epithelial cells: 226 nCPM
- goblet cells: 213 nCPM
- colonocytes: 184 nCPM
- pancreatic acinar cells: 183 nCPM
- renal collecting duct principal cells: 154 nCPM
Immune cell
- memory CD4 T-cell: 0.4 nTPM
- gdT-cell: 0.3 nTPM
- naive CD4 T-cell: 0.3 nTPM
- memory CD8 T-cell: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
- total PBMC: 0.2 nTPM
Brain region
- thalamus: 1.1 nTPM
- cerebral cortex: 1 nTPM
- choroid plexus: 0.9 nTPM
- basal ganglia: 0.8 nTPM
- cerebellum: 0.8 nTPM
- hypothalamus: 0.8 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TTMP.
Disease | AllUniProt
Conditions TTMP is implicated in, by any mechanism.
- Hypotrichosis 15 (HYPT15) MIM:620177
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TPA-induced transmembrane protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TTMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TTMP as an antibody target. Whether an autoantibody or antibody against TTMP could matter depends on whether native TTMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TTMP is annotated at the cell surface, where native TTMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TTMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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