Seroatlas · Human Serome Atlas

SIGLECL1

SIGLEC family-like protein 1

Also known as: C19orf75, FLJ40235, SIGL1_HUMAN, SIGLEC23P, SIGLECP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7X8
Gene: SIGLECL1
Ensembl: ENSG00000179213
Chromosome: 19
Canonical length: 197 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q8N7X8|SIGLECL1
     1  MLPLLQLVPA KLLNSSCSLE KTLQCSCSFH GIPTPSVQWW MGGVPVGVDG MDGSLQVTST
    61  MLGPWANSTI SLTEEPEMGM RLLCEGKNQN GTHALSILLM SRKSSLAAQA FVKGLIQGAI
   121  YAGIVIALLF LCLLPLIVKH IRKKQAKKAA AIRAKKSSKV RASQELEMSL KPEEPGKPVV
   181  ATFSESRILE KQDKRAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIGLECL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
cervix: 0.2 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

late primary spermatocytes: 141 nCPM
late spermatids: 121 nCPM
early primary spermatocytes: 40 nCPM
early spermatids: 34 nCPM
undifferentiated spermatogonia: 6.5 nCPM
differentiating spermatogonia: 5 nCPM

Immune cell

myeloid DC: 0.5 nTPM
classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.2 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.1 nTPM
spinal cord: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIGLECL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TTMP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIGLECL1 as an antibody target. Whether an autoantibody or antibody against SIGLECL1 could matter depends on whether native SIGLECL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIGLECL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIGLECL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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