TTC9C
Tetratricopeptide repeat protein 9C
Also known as: MGC29649, TTC9C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N5M4
- Gene
- TTC9C
- Ensembl
- ENSG00000162222
- Chromosome
- 11
- Canonical length
- 171 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for TTC9C in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
171 residues, UniProt reviewed canonical sequence.
>Q8N5M4|TTC9C
1 MEKRLQEAQL YKEEGNQRYR EGKYRDAVSR YHRALLQLRG LDPSLPSPLP NLGPQGPALT
61 PEQENILHTT QTDCYNNLAA CLLQMEPVNY ERVREYSQKV LERQPDNAKA LYRAGVAFFH
121 LQDYDQARHY LLAAVNRQPK DANVRRYLQL TQSELSSYHR KEKQLYLGMF GLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TTC9C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 24 nTPM
- ovary: 24 nTPM
- thymus: 23 nTPM
- tonsil: 22 nTPM
- duodenum: 19 nTPM
- cerebral cortex: 19 nTPM
Single-cell type
- oocytes: 341 nCPM
- extravillous trophoblasts: 53 nCPM
- hofbauer cells: 52 nCPM
- thymocytes: 47 nCPM
- migrating cytotrophoblasts: 46 nCPM
- paneth cells: 46 nCPM
Immune cell
- basophil: 70 nTPM
- memory B-cell: 43 nTPM
- eosinophil: 41 nTPM
- T-reg: 40 nTPM
- classical monocyte: 39 nTPM
- naive B-cell: 38 nTPM
Brain region
- cerebral cortex: 24 nTPM
- pons: 23 nTPM
- cerebellum: 22 nTPM
- white matter: 21 nTPM
- thalamus: 20 nTPM
- hypothalamus: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.8
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TTC9C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TTC9C as an antibody target. Whether an autoantibody or antibody against TTC9C could matter depends on whether native TTC9C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TTC9C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TTC9C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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