Seroatlas · Human Serome Atlas

TTC17

Tetratricopeptide repeat protein 17

Also known as: FLJ10890, TTC17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96AE7
Gene
TTC17
Ensembl
ENSG00000052841
Chromosome
11
Canonical length
1141 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Involved in actin filament polymerization and cilium organization. Located in actin cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1141 residues, UniProt reviewed canonical sequence.

>Q96AE7|TTC17
     1  MAAAVGVRGR YELPPCSGPG WLLSLSALLS VAARGAFATT HWVVTEDGKI QQQVDSPMNL
    61  KHPHDLVILM RQEATVNYLK ELEKQLVAQK IHIEENEDRD TGLEQRHNKE DPDCIKAKVP
   121  LGDLDLYDGT YITLESKDIS PEDYIDTESP VPPDPEQPDC TKILELPYSI HAFQHLRGVQ
   181  ERVNLSAPLL PKEDPIFTYL SKRLGRSIDD IGHLIHEGLQ KNTSSWVLYN MASFYWRIKN
   241  EPYQVVECAM RALHFSSRHN KDIALVNLAN VLHRAHFSAD AAVVVHAALD DSDFFTSYYT
   301  LGNIYAMLGE YNHSVLCYDH ALQARPGFEQ AIKRKHAVLC QQKLEQKLEA QHRSLQRTLN
   361  ELKEYQKQHD HYLRQQEILE KHKLIQEEQI LRNIIHETQM AKEAQLGNHQ ICRLVNQQHS
   421  LHCQWDQPVR YHRGDIFENV DYVQFGEDSS TSSMMSVNFD VQSNQSDIND SVKSSPVAHS
   481  ILWIWGRDSD AYRDKQHILW PKRADCTESY PRVPVGGELP TYFLPPENKG LRIHELSSDD
   541  YSTEEEAQTP DCSITDFRKS HTLSYLVKEL EVRMDLKAKM PDDHARKILL SRINNYTIPE
   601  EEIGSFLFHA INKPNAPIWL ILNEAGLYWR AVGNSTFAIA CLQRALNLAP LQYQDVPLVN
   661  LANLLIHYGL HLDATKLLLQ ALAINSSEPL TFLSLGNAYL ALKNISGALE AFRQALKLTT
   721  KCPECENSLK LIRCMQFYPF LYNITSSVCS GTVVEESNGS DEMENSDETK MSEEILALVD
   781  EFQQAWPLEG FGGALEMKGR RLDLQGIRVL KKGPQDGVAR SSCYGDCRSE DDEATEWITF
   841  QVKRVKKPKG DHKKTPGKKV ETGQIENGHR YQANLEITGP KVASPGPQGK KRDYQRLGWP
   901  SPDECLKLRW VELTAIVSTW LAVSSKNIDI TEHIDFATPI QQPAMEPLCN GNLPTSMHTL
   961  DHLHGVSNRA SLHYTGESQL TEVLQNLGKD QYPQQSLEQI GTRIAKVLEK NQTSWVLSSM
  1021  AALYWRVKGQ GKKAIDCLRQ ALHYAPHQMK DVPLISLANI LHNAKLWNDA VIVATMAVEI
  1081  APHFAVNHFT LGNVYVAMEE FEKALVWYES TLKLQPEFVP AKNRIQTIQC HLMLKKGRRS
  1141  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 45 nTPM
  • salivary gland: 37 nTPM
  • liver: 35 nTPM
  • thyroid gland: 33 nTPM
  • ovary: 31 nTPM
  • placenta: 26 nTPM

Single-cell type

  • sertoli cells: 478 nCPM
  • myonuclei: 468 nCPM
  • corticotrophs: 438 nCPM
  • choroid plexus epithelial cells: 422 nCPM
  • microglia: 405 nCPM
  • lactotrophs: 386 nCPM

Immune cell

  • intermediate monocyte: 22 nTPM
  • classical monocyte: 21 nTPM
  • non-classical monocyte: 20 nTPM
  • eosinophil: 19 nTPM
  • basophil: 19 nTPM
  • neutrophil: 18 nTPM

Brain region

  • choroid plexus: 45 nTPM
  • cerebellum: 35 nTPM
  • thalamus: 27 nTPM
  • white matter: 27 nTPM
  • midbrain: 27 nTPM
  • medulla oblongata: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
1.3
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC17 as an antibody target. Whether an autoantibody or antibody against TTC17 could matter depends on whether native TTC17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC17 is annotated at the cell surface, where native TTC17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TTC17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TTC17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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