Seroatlas · Human Serome Atlas

CATIP

Ciliogenesis-associated TTC17-interacting protein

Also known as: C2orf62, CATIP_HUMAN, MGC50811

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7H3
Gene
CATIP
Ensembl
ENSG00000158428
Chromosome
2
Canonical length
387 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Connecting piece,Mid piece

OverviewNCBI Gene

Involved in actin filament polymerization and cilium organization. Located in several cellular components, including actin cytoskeleton; nucleus; and plasma membrane. Implicated in spermatogenic failure 54. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

387 residues, UniProt reviewed canonical sequence.

>Q7Z7H3|CATIP
     1  MSSKVYSTGS RAKDHQPSGP ECLPLPEANA EAIDFLSSLH KEELQMLFFS ETLAMVSDTG
    61  EPQGELTIEV QRGKYQEKLG MLTYCLFVHA SSRGFLDKML CGNSLLGYLS EKLELMEQHS
   121  QDFIKFLILP MERKMSLLKQ DDQLAVTRSI KEGEEVKTGV TSFPWSSIKG FISEAANLVL
   181  LRVMAWRRMV PSNARFLTLD TEGKLCYLTY QNLGFQTIQV DHQQAEVFIV EQTVHAEEGI
   241  PMSCQYYLLS DGHLAKRIQV GSPGCCIITK MPILREEDEI EPRPVFEKKP LVWEEDMELY
   301  SKFLDRKEEL RLGHASYLRQ HPEAHALISD FLLFLLLRQP EDVVTFAAEF FGPFDPWRPS
   361  SPALGSSHRP NPFRSLEPEG DARSGAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CATIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 19 nTPM
  • choroid plexus: 15 nTPM
  • testis: 7 nTPM
  • epididymis: 4.6 nTPM
  • kidney: 4.1 nTPM
  • thyroid gland: 3.4 nTPM

Single-cell type

  • respiratory ciliated cells: 113 nCPM
  • fallopian tube ciliated cells: 111 nCPM
  • epididymal efferent duct ciliated cells: 78 nCPM
  • ependymal cells: 75 nCPM
  • endometrial ciliated cells: 42 nCPM
  • late primary spermatocytes: 37 nCPM

Immune cell

  • intermediate monocyte: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 12 nTPM
  • midbrain: 6.4 nTPM
  • medulla oblongata: 5 nTPM
  • spinal cord: 4.7 nTPM
  • hypothalamus: 2.5 nTPM
  • white matter: 2.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CATIP.

Disease | AllUniProt

Conditions CATIP is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 55 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 54

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ciliogenesis-associated TTC17-interacting protein, dimerization/docking domain
  • Ciliogenesis-associated TTC17-interacting protein, N-terminal domain
  • Ciliogenesis-associated TTC17-interacting protein, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CATIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CATIP as an antibody target. Whether an autoantibody or antibody against CATIP could matter depends on whether native CATIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CATIP is annotated at the cell surface, where native CATIP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CATIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CATIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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