Seroatlas · Human Serome Atlas

TSPAN2

Tetraspanin-2

Also known as: FLJ12082, TSN2, TSN2_HUMAN, TSPAN-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60636
Gene: TSPAN2
Ensembl: ENSG00000134198
Chromosome: 1
Canonical length: 221 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>O60636|TSPAN2
     1  MGRFRGGLRC IKYLLLGFNL LFWLAGSAVI AFGLWFRFGG AIKELSSEDK SPEYFYVGLY
    61  VLVGAGALMM AVGFFGCCGA MRESQCVLGS FFTCLLVIFA AEVTTGVFAF IGKGVAIRHV
   121  QTMYEEAYND YLKDRGKGNG TLITFHSTFQ CCGKESSEQV QPTCPKELLG HKNCIDEIET
   181  IISVKLQLIG IVGIGIAGLT IFGMIFSMVL CCAIRNSRDV I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TSPAN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

colon: 48 nTPM
blood vessel: 42 nTPM
endometrium: 41 nTPM
smooth muscle: 40 nTPM
fallopian tube: 28 nTPM
seminal vesicle: 27 nTPM

Single-cell type

podocytes: 313 nCPM
neutrophil progenitors: 205 nCPM
smooth muscle cells: 179 nCPM
neutrophils: 169 nCPM
pancreatic islet cells: 85 nCPM
platelets: 58 nCPM

Immune cell

neutrophil: 110 nTPM
basophil: 110 nTPM
NK-cell: 87 nTPM
eosinophil: 56 nTPM
memory CD8 T-cell: 23 nTPM
memory CD4 T-cell: 21 nTPM

Brain region

thalamus: 12 nTPM
pons: 12 nTPM
midbrain: 8.8 nTPM
hypothalamus: 8.1 nTPM
amygdala: 7.5 nTPM
medulla oblongata: 7.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TSPAN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TSPAN2 as an antibody target. Whether an autoantibody or antibody against TSPAN2 could matter depends on whether native TSPAN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TSPAN2 is annotated at the cell surface, where native TSPAN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TSPAN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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