Seroatlas · Human Serome Atlas

TRMO

tRNA (adenine(37)-N6)-methyltransferase

Also known as: C9orf156, HSPC219, TRMO_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BU70
Gene
TRMO
Ensembl
ENSG00000136932
Chromosome
9
Canonical length
441 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9BU70|TRMO
     1  MRGLEESGPR PTATPCGCVK PALETGNLLT EPVGYLESCF SAKNGTPRQP SICSYSRACL
    61  RIRKRIFNNP EHSLMGLEQF SHVWILFVFH KNGHLSCKAK VQPPRLNGAK TGVFSTRSPH
   121  RPNAIGLTLA KLEKVEGGAI YLSGIDMIHG TPVLDIKPYI AEYDSPQNVM EPLADFNLQN
   181  NQHTPNTVSQ SDSKTDSCDQ RQLSGCDEPQ PHHSTKRKPK CPEDRTSEEN YLTHSDTARI
   241  QQAFPMHREI AVDFGLESRR DQSSSVAEEQ IGPYCPEKSF SEKGTDKKLE RVEGAAVLQG
   301  SRAETQPMAP HCPAGRADGA PRSVVPAWVT EAPVATLEVR FTPHAEMDLG QLSSQDVGQA
   361  SFKYFQSAEE AKRAIEAVLS ADPRSVYRRK LCQDRLFYFT VDIAHVTCWF GDGFAEVLRI
   421  KPASEPVHMT GPVGSLVSLG S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 18 nTPM
  • bone marrow: 17 nTPM
  • lymph node: 15 nTPM
  • tonsil: 14 nTPM
  • breast: 13 nTPM
  • thymus: 13 nTPM

Single-cell type

  • neutrophils: 152 nCPM
  • innate lymphoid cells: 97 nCPM
  • t-cells: 80 nCPM
  • cdc: 63 nCPM
  • mast cells: 62 nCPM
  • b-cells: 55 nCPM

Immune cell

  • eosinophil: 52 nTPM
  • basophil: 47 nTPM
  • naive CD4 T-cell: 42 nTPM
  • T-reg: 37 nTPM
  • neutrophil: 35 nTPM
  • memory CD4 T-cell: 32 nTPM

Brain region

  • white matter: 17 nTPM
  • choroid plexus: 16 nTPM
  • basal ganglia: 14 nTPM
  • medulla oblongata: 13 nTPM
  • hypothalamus: 13 nTPM
  • cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family UPF0066, conserved site
  • TrmO-like, N-terminal domain
  • YaeB-like superfamily
  • YaeB, N-terminal domain superfamily
  • YaeB-like
  • tRNA-methyltransferase O N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMO as an antibody target. Whether an autoantibody or antibody against TRMO could matter depends on whether native TRMO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRMO. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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