TRAV8-6

Protein identityUniProt · HPA

UniProt accession

A0A0B4J262

Gene

TRAV8-6

Ensembl

ENSG00000211795

Chromosome

14

Canonical length

113 aa

Protein class

Predicted intracellular proteins, T-cell receptor genes

Quaternary structure

Homodimer

OverviewNCBI Gene

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>A0A0B4J262|TRAV8-6
     1  MLLLLVPAFQ VIFTLGGTRA QSVTQLDSQV PVFEEAPVEL RCNYSSSVSV YLFWYVQYPN
    61  QGLQLLLKYL SGSTLVESIN GFEAEFNKSQ TSFHLRKPSV HISDTAEYFC AVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAV8-6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Highest tissue expression

23 nTPM

Expression across tissuesHPA

OntologyGO

Biological processes

• adaptive immune response

Cellular components

• T cell receptor complex

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• T cell receptor variable region
• Immunoglobulin V-set domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Membrane
• Receptor
• Signal
• T cell receptor