T cell receptor variable region
IPR051287
Definition
The T cell receptor (TCR) variable region family is involved in antigen recognition and is essential for the immune response. TCRs are present on the surface of T lymphocytes and recognize peptide-major histocompatibility (MH) complexes displayed by antigen presenting cells (APCs). The interaction between TCRs and pMH complexes initiates a cascade of intracellular signaling events that lead to T cell activation, growth, and differentiation. The signaling pathways include calcium, mitogen-activated protein kinase (MAPK) kinase, and nuclear factor NF-kappa-B (NF-kB) pathways. TCR diversity is generated in the thymus through V-(D)-J rearrangement and is further shaped by selection events to produce a repertoire of self-MH restricted, non-autoaggressive T cells. The family includes both alpha-beta and gamma-delta TCRs, with alpha-beta TCRs recognizing peptides and gamma-delta TCRs recognizing a variety of self and foreign non-peptide antigens.
18 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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