Seroatlas · Human Serome Atlas

TRARG1

Trafficking regulator of GLUT4 1

Also known as: BEC-1, DSPB1, IFITMD3, LOST1, TARG1_HUMAN, TUSC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXB3
Gene: TRARG1
Ensembl: ENSG00000184811
Chromosome: 17
Canonical length: 177 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Predicted to act upstream of or within establishment of localization in cell and vesicle fusion to plasma membrane. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q8IXB3|TRARG1
     1  MAHPVQSEFP SAQEPGSAAF LDLPEMEILL TKAENKDDKT LNLSKTLSGP LDLEQNSQGL
    61  PFKAISEGHL EAPLPRSPSR ASSRRASSIA TTSYAQDQEA PRDYLILAVV ACFCPVWPLN
   121  LIPLIISIMS RSSMQQGNVD GARRLGRLAR LLSITLIIMG IVIIMVAVTV NFTVQKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRARG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 95 nTPM
breast: 68 nTPM
blood vessel: 18 nTPM
salivary gland: 2.3 nTPM
skin: 2 nTPM
heart muscle: 1.6 nTPM

Single-cell type

adipocytes: 87 nCPM
cdc: 2 nCPM
undifferentiated spermatogonia: 1.6 nCPM
pdcs: 1.3 nCPM
retinal amacrine cells: 1.1 nCPM
mucous neck cells: 0.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
pons: 0.4 nTPM
white matter: 0.4 nTPM
midbrain: 0.3 nTPM
basal ganglia: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to insulin stimulus
endosome to plasma membrane protein transport
glucose import in response to insulin stimulus
protein localization to plasma membrane
vesicle fusion to plasma membrane

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRARG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SLC2A4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRARG1 as an antibody target. Whether an autoantibody or antibody against TRARG1 could matter depends on whether native TRARG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRARG1 is annotated at the cell surface, where native TRARG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRARG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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