Seroatlas · Human Serome Atlas

TOP6BL

Type 2 DNA topoisomerase 6 subunit B-like

Also known as: C11orf80, FLJ22531, TO6BL_HUMAN, TOPOVIBL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6T0
Gene
TOP6BL
Ensembl
ENSG00000173715
Chromosome
11
Canonical length
511 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Centrosome

OverviewNCBI Gene

Predicted to be involved in meiotic DNA double-strand break formation and reciprocal meiotic recombination. Predicted to be located in chromosome. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>Q8N6T0|TOP6BL
     1  MVLKKFLKEI QSILPGISAK LTWTSEEGSY SQDMTGVTPF QMIFEVDEKP RTLMTDCLVI
    61  KHFLRKIIMV HPKVRFHFSV KVNGILSTEI FGVENEPTLN LGNGIALLVD SQHYVSRPNF
   121  GTIESHCSRI HPVLGHPVML FIPEDVAGMD LLGELILTPA AALCPSPKVS SNQLNRISSV
   181  SIFLYGPLGL PLILSTWEQP MTTFFKDTSS LVDWKKYHLC MIPNLDLNLD RDLVLPDVSY
   241  QVESSEEDQS QTMDPQGQTL LLFLFVDFHS AFPVQQMEIW GVYTLLTTHL NAILVESHSV
   301  VQGSIQFTVD KVLEQHHQAA KAQQKLQASL SVAVNSIMSI LTGSTRSSFR KMCLQTLQAA
   361  DTQEFRTKLH KVFREITQHQ FLHHCSCEVK QLTLEKKDSA QGTEDAPDNS SLELLADTSG
   421  QAENKRLKRG SPRIEEMRAL RSARAPSPSE AAPRRPEATA APLTPRGREH REAHGRALAP
   481  GRASLGSRLE DVLWLQEVSN LSEWLSPSPG P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOP6BL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • skin: 39 nTPM
  • testis: 24 nTPM
  • esophagus: 23 nTPM
  • cerebellum: 23 nTPM
  • kidney: 23 nTPM
  • salivary gland: 14 nTPM

Single-cell type

  • renal collecting duct principal cells: 584 nCPM
  • renal connecting tubule cells: 464 nCPM
  • renal collecting duct intercalated cells: 435 nCPM
  • cone photoreceptor cells: 261 nCPM
  • papillary tip epithelial cells: 209 nCPM
  • gonadotrophs: 201 nCPM

Immune cell

  • memory B-cell: 11 nTPM
  • plasmacytoid DC: 9.1 nTPM
  • naive B-cell: 7.4 nTPM
  • T-reg: 4 nTPM
  • MAIT T-cell: 3.6 nTPM
  • naive CD4 T-cell: 3.5 nTPM

Brain region

  • cerebellum: 45 nTPM
  • cerebral cortex: 33 nTPM
  • basal ganglia: 28 nTPM
  • hypothalamus: 28 nTPM
  • amygdala: 27 nTPM
  • white matter: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TOP6BL.

Disease | AllUniProt

Conditions TOP6BL is implicated in, by any mechanism.

  • Hydatidiform mole, recurrent, 4 (HYDM4) MIM:618432

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 42 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Type 2 DNA topoisomerase 6 subunit B-like
  • Domain of unknown function (DUF4554)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOP6BL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOP6BL as an antibody target. Whether an autoantibody or antibody against TOP6BL could matter depends on whether native TOP6BL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOP6BL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOP6BL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOP6BL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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