Seroatlas · Human Serome Atlas

TOGARAM1

TOG array regulator of axonemal microtubules protein 1

Also known as: crescerin, Crescerin-1, FAM179B, KIAA0423, TGRM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4F4
Gene: TOGARAM1
Ensembl: ENSG00000198718
Chromosome: 14
Canonical length: 1720 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Microtubules,Primary cilium

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in cilium assembly. Located in axoneme. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1720 residues, UniProt reviewed canonical sequence.

>Q9Y4F4|TOGARAM1
     1  MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF RGAAGDHGSC
    61  PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL QLLRTARDPS EAFQALQAAL
   121  PRRGGRLGFP RRKEALYRAL GRVLVEGGSD EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL
   181  LPQLVVSLRE ENPALRKDAL QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI
   241  LLTTEDLLLG LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP
   301  SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI IPQELHSRLL
   361  DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY NLLDDSNFKV VHGTLEVLHL
   421  LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK
   481  HKHSRVREEV VNICICSLLT YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS
   541  MGSGKTSILF KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR
   601  SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL SAGKGKNKLP
   661  WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM PVNDDLCFSR KRVSRNLFQN
   721  SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ LGFSQICGKT GSVGSDLQFL GTTSSHQEKV
   781  YASLNFGSKT QQTFGSQTEC TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS
   841  QDNSVNFSNS WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS
   901  PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL PIDLSELNFK
   961  DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA MKLDLTMDSP SLSSSPNINS
  1021  YSESGVYSQE SLTSSLSTTP QGKRIMSDIF PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG
  1081  SSSNPQQISS FDFTTTKALS EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ
  1141  SIEPPSGIYG RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK
  1201  EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR PFSKPEIALT
  1261  EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN FAVVQEVKNL RSGVSRAAVV
  1321  CLSDLFTYLK KSMDQELDTT VKVLLHKAGE SNTFIREDVD KALRAMVNNV TPARAVVSLI
  1381  NGGQRYYGRK MLFFMMCHPN FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK
  1441  GRRSHTGSVG NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA
  1501  KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA LETMHKMIPL
  1561  LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS QHVDNYLLLQ PFCTKAQFLN
  1621  GKAKQDMTEK LADIVTELYQ RKPHATEQKV LVVLWHLLGN MTNSGSLPGA GGNIRTATAK
  1681  LSKALFAQMG QNLLNQAASQ PPHIKKSLEE LLDMTILNEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOGARAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

retina: 16 nTPM
skeletal muscle: 12 nTPM
tongue: 11 nTPM
cerebellum: 9.8 nTPM
cerebral cortex: 9.8 nTPM
fallopian tube: 9.8 nTPM

Single-cell type

endometrial ciliated cells: 286 nCPM
respiratory ciliated cells: 221 nCPM
cone photoreceptor cells: 215 nCPM
ependymal cells: 215 nCPM
oligodendrocytes: 201 nCPM
rod photoreceptor cells: 194 nCPM

Immune cell

basophil: 4.8 nTPM
eosinophil: 1 nTPM
NK-cell: 0.8 nTPM
plasmacytoid DC: 0.7 nTPM
memory CD4 T-cell: 0.6 nTPM
myeloid DC: 0.6 nTPM

Brain region

white matter: 49 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 35 nTPM
hippocampal formation: 32 nTPM
cerebellum: 31 nTPM
choroid plexus: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TOGARAM1.

Disease | AllUniProt

Conditions TOGARAM1 is implicated in, by any mechanism.

Joubert syndrome 37 (JBTS37) MIM:619185

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 307 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Joubert syndrome 37
Joubert syndrome
Ciliopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOGARAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOGARAM1 as an antibody target. Whether an autoantibody or antibody against TOGARAM1 could matter depends on whether native TOGARAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOGARAM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOGARAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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