Seroatlas · Human Serome Atlas

TNFAIP2

Tumor necrosis factor alpha-induced protein 2

Also known as: B94, EXOC3L3, TNAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q03169
Gene: TNFAIP2
Ensembl: ENSG00000185215
Chromosome: 14
Canonical length: 654 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear membrane,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

654 residues, UniProt reviewed canonical sequence.

>Q03169|TNFAIP2
     1  MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA
    61  EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR
   121  RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA
   181  TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP
   241  AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ
   301  GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL
   361  AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA
   421  NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF
   481  THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL
   541  KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY
   601  ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 259 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 259 nTPM
spleen: 139 nTPM
lung: 134 nTPM
adipose tissue: 111 nTPM
bone marrow: 101 nTPM
appendix: 98 nTPM

Single-cell type

endometrial secretory cells: 657 nCPM
neutrophils: 442 nCPM
fallopian secretory cells: 421 nCPM
monocytes: 298 nCPM
prostatic club cells: 230 nCPM
endometrial glandular cells: 230 nCPM

Immune cell

neutrophil: 49 nTPM
intermediate monocyte: 19 nTPM
classical monocyte: 17 nTPM
non-classical monocyte: 15 nTPM
myeloid DC: 9.4 nTPM
eosinophil: 9 nTPM

Brain region

thalamus: 54 nTPM
medulla oblongata: 43 nTPM
white matter: 40 nTPM
pons: 40 nTPM
cerebral cortex: 36 nTPM
spinal cord: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 2.04
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SNARE binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP2 as an antibody target. Whether an autoantibody or antibody against TNFAIP2 could matter depends on whether native TNFAIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP2 is annotated as secreted, so native TNFAIP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TNFAIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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