TMX4
Thioredoxin-related transmembrane protein 4
Also known as: DJ971N18.2, KIAA1162, PDIA14, TMX4_HUMAN, TXNDC13
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H1E5
- Gene
- TMX4
- Ensembl
- ENSG00000125827
- Chromosome
- 20
- Canonical length
- 349 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nuclear membrane
OverviewNCBI Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
Canonical amino-acid sequenceUniProt
349 residues, UniProt reviewed canonical sequence.
>Q9H1E5|TMX4
1 MAGGRCGPQL TALLAAWIAA VAATAGPEEA ALPPEQSRVQ PMTASNWTLV MEGEWMLKFY
61 APWCPSCQQT DSEWEAFAKN GEILQISVGK VDVIQEPGLS GRFFVTTLPA FFHAKDGIFR
121 RYRGPGIFED LQNYILEKKW QSVEPLTGWK SPASLTMSGM AGLFSISGKI WHLHNYFTVT
181 LGIPAWCSYV FFVIATLVFG LFMGLVLVVI SECFYVPLPR HLSERSEQNR RSEEAHRAEQ
241 LQDAEEEKDD SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEDNLAAGVD EERSEANDQG
301 PPGEDGVTRE EVEPEEAEEG ISEQPCPADT EVVEDSLRQR KSQHADKGLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 61 nTPM
Expression across tissuesHPA
Tissue
- testis: 61 nTPM
- heart muscle: 56 nTPM
- seminal vesicle: 40 nTPM
- cervix: 39 nTPM
- adrenal gland: 37 nTPM
- parathyroid gland: 36 nTPM
Single-cell type
- late spermatids: 2,316 nCPM
- early spermatids: 754 nCPM
- neutrophils: 548 nCPM
- late primary spermatocytes: 446 nCPM
- monocyte progenitors: 406 nCPM
- lacrimal acinar cells: 393 nCPM
Immune cell
- neutrophil: 165 nTPM
- basophil: 82 nTPM
- eosinophil: 79 nTPM
- memory CD8 T-cell: 56 nTPM
- T-reg: 55 nTPM
- total PBMC: 53 nTPM
Brain region
- hypothalamus: 139 nTPM
- thalamus: 89 nTPM
- choroid plexus: 82 nTPM
- medulla oblongata: 82 nTPM
- cerebral cortex: 76 nTPM
- midbrain: 74 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.03
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMX4 as an antibody target. Whether an autoantibody or antibody against TMX4 could matter depends on whether native TMX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMX4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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