Seroatlas · Human Serome Atlas

TMT1A

Thiol S-methyltransferase TMT1A

Also known as: DKFZP586A0522, METTL7A, TMT1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8H3
Gene: TMT1A
Ensembl: ENSG00000185432
Chromosome: 12
Canonical length: 244 aa
Protein class: Predicted membrane proteins
Subcellular location: Lipid droplets

OverviewNCBI Gene

Enables mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q9H8H3|TMT1A
     1  MELTIFILRL AIYILTFPLY LLNFLGLWSW ICKKWFPYFL VRFTVIYNEQ MASKKRELFS
    61  NLQEFAGPSG KLSLLEVGCG TGANFKFYPP GCRVTCIDPN PNFEKFLIKS IAENRHLQFE
   121  RFVVAAGENM HQVADGSVDV VVCTLVLCSV KNQERILREV CRVLRPGGAF YFMEHVAAEC
   181  STWNYFWQQV LDPAWHLLFD GCNLTRESWK ALERASFSKL KLQHIQAPLS WELVRPHIYG
   241  YAVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMT1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 395 nTPM

Expression across tissuesHPA

Tissue

liver: 395 nTPM
thyroid gland: 225 nTPM
adipose tissue: 133 nTPM
kidney: 131 nTPM
pancreas: 108 nTPM
fallopian tube: 82 nTPM

Single-cell type

ependymal cells: 131 nCPM
astrocytes: 122 nCPM
bergmann glia: 108 nCPM
microglia: 106 nCPM
papillary tip epithelial cells: 77 nCPM
proximal tubule cells: 72 nCPM

Immune cell

basophil: 95 nTPM
eosinophil: 70 nTPM
non-classical monocyte: 59 nTPM
intermediate monocyte: 37 nTPM
classical monocyte: 35 nTPM
naive B-cell: 34 nTPM

Brain region

midbrain: 191 nTPM
medulla oblongata: 190 nTPM
basal ganglia: 171 nTPM
thalamus: 168 nTPM
choroid plexus: 165 nTPM
hypothalamus: 163 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMT1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMT1A as an antibody target. Whether an autoantibody or antibody against TMT1A could matter depends on whether native TMT1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMT1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMT1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...