Seroatlas · Human Serome Atlas

TMPRSS11F

Transmembrane protease serine 11F

Also known as: FLJ16046, HATL4, TM11F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZWK6
Gene: TMPRSS11F
Ensembl: ENSG00000198092
Chromosome: 4
Canonical length: 438 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within establishment of skin barrier. Located in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q6ZWK6|TMPRSS11F
     1  MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH FVVEDDKSFY
    61  YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR HSSVGGRFIK SHVIKLSPDE
   121  QGVDILIVLI FRYPSTDSAE QIKKKIEKAL YQSLKTKQLS LTINKPSFRL TPIDSKKMRN
   181  LLNSRCGIRM TSSNMPLPAS SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN
   241  TWLLTAAHCF WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
   301  TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV ETISTDVCNR
   361  KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI WYIVGIVSWG QSCALPKKPG
   421  VYTRVTKYRD WIASKTGM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS11F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

esophagus: 14 nTPM
skin: 8.8 nTPM
cervix: 4.9 nTPM
vagina: 4.7 nTPM
tonsil: 3.8 nTPM
breast: 1 nTPM

Single-cell type

esophageal apical cells: 287 nCPM
esophageal suprabasal cells: 64 nCPM
suprabasal keratinocytes: 42 nCPM
ocular epithelial cells: 26 nCPM
retinal ganglion cells: 19 nCPM
esophageal basal cells: 6.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 1.7 nTPM
cerebral cortex: 1.3 nTPM
medulla oblongata: 1.3 nTPM
basal ganglia: 1.1 nTPM
hypothalamus: 1.1 nTPM
thalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS11F as an antibody target. Whether an autoantibody or antibody against TMPRSS11F could matter depends on whether native TMPRSS11F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS11F is annotated at the cell surface, where native TMPRSS11F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS11F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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