Seroatlas · Human Serome Atlas

TMPRSS11E

Transmembrane protease serine 11E

Also known as: DESC1, TM11E_HUMAN, TMPRSS11E2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL52
Gene: TMPRSS11E
Ensembl: ENSG00000087128
Chromosome: 4
Canonical length: 423 aa
Protein class: Enzymes, Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable serine-type peptidase activity. Involved in cognition. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9UL52|TMPRSS11E
     1  MMYRPDVVRA RKRVCWEPWV IGLVIFISLI VLAVCIGLTV HYVRYNQKKT YNYYSTLSFT
    61  TDKLYAEFGR EASNNFTEMS QRLESMVKNA FYKSPLREEF VKSQVIKFSQ QKHGVLAHML
   121  LICRFHSTED PETVDKIVQL VLHEKLQDAV GPPKVDPHSV KIKKINKTET DSYLNHCCGT
   181  RRSKTLGQSL RIVGGTEVEE GEWPWQASLQ WDGSHRCGAT LINATWLVSA AHCFTTYKNP
   241  ARWTASFGVT IKPSKMKRGL RRIIVHEKYK HPSHDYDISL AELSSPVPYT NAVHRVCLPD
   301  ASYEFQPGDV MFVTGFGALK NDGYSQNHLR QAQVTLIDAT TCNEPQAYND AITPRMLCAG
   361  SLEGKTDACQ GDSGGPLVSS DARDIWYLAG IVSWGDECAK PNKPGVYTRV TALRDWITSK
   421  TGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPRSS11E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 210 nTPM

Expression across tissuesHPA

Tissue

esophagus: 210 nTPM
vagina: 156 nTPM
cervix: 116 nTPM
salivary gland: 50 nTPM
tonsil: 23 nTPM
epididymis: 17 nTPM

Single-cell type

esophageal apical cells: 676 nCPM
salivary ionocytes: 331 nCPM
respiratory ionocytes: 71 nCPM
prostatic hillock cells: 25 nCPM
esophageal suprabasal cells: 25 nCPM
salivary duct cells: 20 nCPM

Immune cell

memory B-cell: 0.2 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPRSS11E as an antibody target. Whether an autoantibody or antibody against TMPRSS11E could matter depends on whether native TMPRSS11E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPRSS11E is annotated at the cell surface, where native TMPRSS11E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMPRSS11E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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