Seroatlas · Human Serome Atlas

TMEM91

Transmembrane protein 91

Also known as: DSPC3, FLJ27310, IFITMD6, TMM91_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNR0
Gene: TMEM91
Ensembl: ENSG00000142046
Chromosome: 19
Canonical length: 172 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q6ZNR0|TMEM91
     1  MDSPSLRELQ QPLLEGTECE TPAQKPGRHE LGSPLREIAF AESLRGLQFL SPPLPSVSAG
    61  LGEPRPPDVE DMSSSDSDSD WDGGSRLSPF LPHDHLGLAV FSMLCCFWPV GIAAFCLAQK
   121  TNKAWAKGDI QGAGAASRRA FLLGVLAVGL GVCTYAAALV TLAAYLASRD PP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 99 nTPM
skin: 66 nTPM
hypothalamus: 55 nTPM
spleen: 39 nTPM
testis: 38 nTPM
cervix: 36 nTPM

Single-cell type

late spermatids: 721 nCPM
platelets: 549 nCPM
early spermatids: 207 nCPM
neutrophils: 114 nCPM
megakaryocytes: 105 nCPM
extravillous trophoblasts: 68 nCPM

Immune cell

neutrophil: 195 nTPM
classical monocyte: 52 nTPM
total PBMC: 41 nTPM
basophil: 37 nTPM
plasmacytoid DC: 15 nTPM
intermediate monocyte: 12 nTPM

Brain region

hypothalamus: 88 nTPM
basal ganglia: 68 nTPM
midbrain: 49 nTPM
amygdala: 39 nTPM
medulla oblongata: 39 nTPM
thalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.03
gnomAD missense Z: 0.65
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

hematopoietic progenitor cell differentiation

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM91 as an antibody target. Whether an autoantibody or antibody against TMEM91 could matter depends on whether native TMEM91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...