Seroatlas · Human Serome Atlas

TMEM40

Transmembrane protein 40

Also known as: FLJ11036, TMM40_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWA1
Gene: TMEM40
Ensembl: ENSG00000088726
Chromosome: 3
Canonical length: 233 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q8WWA1|TMEM40
     1  METSASSSQP QDNSQVHRET EDVDYGETDF HKQDGKAGLF SQEQYERNKS SSSSSSSSSS
    61  SSSSSSSSSS ESNDEDQQPR ATGKHRRSLG AGYPHGNGSP GPGHGEPDVL KDELQLYGDA
   121  PGEVVPSGES GLRRRGSDPA SGEVEASQLR RLNIKKDDEF FHFVLLCFAI GALLVCYHYY
   181  ADWFMSLGVG LLTFASLETV GIYFGLVYRI HSVLQGFIPL FQKFRLTGFR KTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 214 nTPM

Expression across tissuesHPA

Tissue

esophagus: 214 nTPM
vagina: 77 nTPM
skin: 62 nTPM
cervix: 55 nTPM
tonsil: 24 nTPM
salivary gland: 24 nTPM

Single-cell type

esophageal apical cells: 5,067 nCPM
platelets: 2,578 nCPM
esophageal suprabasal cells: 1,124 nCPM
syncytiotrophoblasts: 1,100 nCPM
suprabasal keratinocytes: 488 nCPM
megakaryocytes: 365 nCPM

Immune cell

total PBMC: 33 nTPM
neutrophil: 6 nTPM
basophil: 1.6 nTPM
eosinophil: 1.1 nTPM
classical monocyte: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

cerebellum: 3.3 nTPM
cerebral cortex: 3.3 nTPM
hypothalamus: 3.2 nTPM
hippocampal formation: 3.1 nTPM
basal ganglia: 3 nTPM
medulla oblongata: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: -0.7
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 40
Transmembrane protein 40 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CFTR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM40 as an antibody target. Whether an autoantibody or antibody against TMEM40 could matter depends on whether native TMEM40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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