Seroatlas · Human Serome Atlas

TMEM265

Transmembrane protein 265

Also known as: TM265_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A087WTH1
Gene: TMEM265
Ensembl: ENSG00000281991
Chromosome: 16
Canonical length: 108 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>A0A087WTH1|TMEM265
     1  MEDEEKAVEI LGNTEAAHPP SPIRCCWLRL RCLAATSIIC GCSCLGVMAL VFAIKAEERH
    61  KAGRSEEAVR WGARARKLIL ASFAVWLAVL ILGPLLLWLL SYAIAQAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM265 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

skin: 12 nTPM
esophagus: 9 nTPM
salivary gland: 5.4 nTPM
vagina: 5 nTPM
kidney: 4.3 nTPM
lung: 3.8 nTPM

Single-cell type

microglia: 12 nCPM
oligodendrocytes: 10 nCPM
astrocytes: 9.1 nCPM
choroid plexus epithelial cells: 8.5 nCPM
bergmann glia: 7.5 nCPM
brain excitatory neurons: 7.3 nCPM

Immune cell

NK-cell: 1.2 nTPM
neutrophil: 1.1 nTPM
memory CD8 T-cell: 0.8 nTPM
memory CD4 T-cell: 0.7 nTPM
naive B-cell: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

white matter: 0.3 nTPM
cerebellum: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM265 as an antibody target. Whether an autoantibody or antibody against TMEM265 could matter depends on whether native TMEM265 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM265 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM265 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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