Seroatlas · Human Serome Atlas

TMEM235

Transmembrane protein 235

Also known as: TM235_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NFC5
Gene
TMEM235
Ensembl
ENSG00000204278
Chromosome
17
Canonical length
223 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>A6NFC5|TMEM235
     1  MARLGALLLA AALGALLSFA LLAAAVASDY WYILEVADAG NGSAWPGRAE LLSSHSGLWR
    61  ICEGQNGCIP LVDPFASESL DVSTSVQHLI LLHRAVIVVL PLSLVLLVCG WICGLLSSLA
   121  QSVSLLLFTG CYFLLGSVLT LAGVSIYISY SHLAFAETVQ QYGPQHMQGV RVSFGWSMAL
   181  AWGSCALEAF SGTLLLSAAW TLSLSPPICG HLSPQQVGGR GGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM235 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 38 nTPM
  • hippocampal formation: 36 nTPM
  • midbrain: 33 nTPM
  • basal ganglia: 31 nTPM
  • amygdala: 22 nTPM
  • hypothalamus: 18 nTPM

Single-cell type

  • oligodendrocytes: 174 nCPM
  • microglia: 2 nCPM
  • other brain neurons: 1.9 nCPM
  • oligodendrocyte progenitor cells: 1.8 nCPM
  • ependymal cells: 1.7 nCPM
  • astrocytes: 1.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 167 nTPM
  • basal ganglia: 112 nTPM
  • cerebral cortex: 100 nTPM
  • medulla oblongata: 92 nTPM
  • thalamus: 86 nTPM
  • midbrain: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
0.49
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM235 as an antibody target. Whether an autoantibody or antibody against TMEM235 could matter depends on whether native TMEM235 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM235 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM235 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM235. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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