Seroatlas · Human Serome Atlas

TMEM209

Transmembrane protein 209

Also known as: FLJ14803, NET31, TM209_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SK2
Gene: TMEM209
Ensembl: ENSG00000146842
Chromosome: 7
Canonical length: 561 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nuclear membrane,Nuclear speckles,Vesicles

OverviewNCBI Gene

Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q96SK2|TMEM209
     1  MMQGEAHPSA SLIDRTIKMR KETEARKVVL AWGLLNVSMA GMIYTEMTGK LISSYYNVTY
    61  WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG QQTLLGLKTA VVQTTPPHDL
   121  AATQIPPAPP SPSIQGQSVL SYSPSRSPST SPKFTTSCMT GYSPQLQGLS SGGSGSYSPG
   181  VTYSPVSGYN KLASFSPSPP SPYPTTVGPV ESSGLRSRYR SSPTVYNSPT DKEDYMTDLR
   241  TLDTFLRSEE EKQHRVKLGS PDSTSPSSSP TFWNYSRSMG DYAQTLKKFQ YQLACRSQAP
   301  CANKDEADLS SKQAAEEVWA RVAMNRQLLD HMDSWTAKFR NWINETILVP LVQEIESVST
   361  QMRRMGCPEL QIGEASITSL KQAALVKAPL IPTLNTIVQY LDLTPNQEYL FERIKELSQG
   421  GCMSSFRWNR GGDFKGRKWD TDLPTDSAII MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV
   481  QTPNKPDVTN ENVFCIYQSA INPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES
   541  GMLGRVNLGL SGVNILWIFG E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM209 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 15 nTPM
adrenal gland: 14 nTPM
parathyroid gland: 14 nTPM
testis: 14 nTPM
thymus: 13 nTPM
retina: 12 nTPM

Single-cell type

early spermatids: 86 nCPM
corticotrophs: 49 nCPM
retinal pigment epithelial cells: 47 nCPM
erythrocyte progenitors: 43 nCPM
thyrotrophs: 40 nCPM
lactotrophs: 37 nCPM

Immune cell

naive CD4 T-cell: 26 nTPM
T-reg: 25 nTPM
MAIT T-cell: 23 nTPM
memory CD4 T-cell: 22 nTPM
naive CD8 T-cell: 22 nTPM
gdT-cell: 22 nTPM

Brain region

choroid plexus: 39 nTPM
white matter: 30 nTPM
cerebellum: 26 nTPM
pons: 25 nTPM
midbrain: 24 nTPM
medulla oblongata: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cytochrome B561-related
Cytochrome B561, N terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM209 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NUP205

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM209 as an antibody target. Whether an autoantibody or antibody against TMEM209 could matter depends on whether native TMEM209 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM209 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM209 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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