Seroatlas · Human Serome Atlas

NUP205

Nuclear pore complex protein Nup205

Also known as: C7orf14, KIAA0225, NU205_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92621
Gene: NUP205
Ensembl: ENSG00000155561
Chromosome: 7
Canonical length: 2012 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

2012 residues, UniProt reviewed canonical sequence.

>Q92621|NUP205
     1  MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN
    61  VQQHEKVQKA STEGVAIQGQ QGTRLLPEQL IKEAFILSDL FDIGELAAVE LLLAGEHQQP
   121  HFPGLTRGLV AVLLYWDGKR CIANSLKALI QSRRGKTWTL ELSPELASMT TRFTDELMEQ
   181  GLTYKVLTLV SQIDVNNEFE KLQRERGLGS EKHRKEVSDL IKECRQSLAE SLFAWACQSP
   241  LGKEDTLLLI GHLERVTVEA NGSLDAVNLA LLMALLYCFD ISFIEQSTEE RDDMIHQLPL
   301  LTEKQYIATI HSRLQDSQLW KLPGLQATVR LAWALALRGI SQLPDVTALA EFTEADEAMA
   361  ELAIADNVFL FLMESVVVSE YFYQEEFYIR RVHNLITDFL ALMPMKVKQL RNRADEDARM
   421  IHMSMQMGNE PPISLRRDLE HLMLLIGELY KKNPFHLELA LEYWCPTEPL QTPTIMGSYL
   481  GVAHQRPPQR QVVLSKFVRQ MGDLLPPTIY IPYLKMLQGL ANGPQCAHYC FSLLKVNGSS
   541  HVENIQGAGG SPVSWEHFFH SLMLYHEHLR KDLPSADSVQ YRHLPSRGIT QKEQDGLIAF
   601  LQLTSTIITW SENARLALCE HPQWTPVVVI LGLLQCSIPP VLKAELLKTL AAFGKSPEIA
   661  ASLWQSLEYT QILQTVRIPS QRQAIGIEVE LNEIESRCEE YPLTRAFCQL ISTLVESSFP
   721  SNLGAGLRPP GFDPYLQFLR DSVFLRFRTR AYRRAAEKWE VAEVVLEVFY KLLRDYEPQL
   781  EDFVDQFVEL QGEEIIAYKP PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK
   841  HLEKAVQHCL ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPRT KKADNVVNIA
   901  RYLYHGNTNP ELAFESAKIL CCISCNSNIQ IKLVGDFTHD QSISQKLMAG FVECLDCEDA
   961  EEFVRLEEGS ELEKKLVAIR HETRIHILNL LITSLECNPP NLALYLLGFE LKKPVSTTNL
  1021  QDPGVLGCPR TCLHAILNIL EKGTEGRTGP VAVRESPQLA ELCYQVIYQL CACSDTSGPT
  1081  MRYLRTSQDF LFSQLQYLPF SNKEYEISML NQMSWLMKTA SIELRVTSLN RQRSHTQRLL
  1141  HLLLDDMPVK PYSDGEGGIE DENRSVSGFL HFDTATKVRR KILNILDSID FSQEIPEPLQ
  1201  LDFFDRAQIE QVIANCEHKN LRGQTVCNVK LLHRVLVAEV NALQGMAAIG QRPLLMEEIS
  1261  TVLQYVVGRN KLLQCLHAKR HALESWRQLV EIILTACPQD LIQAEDRQLI IRDILQDVHD
  1321  KILDDEAAQE LMPVVAGAVF TLTAHLSQAV LTEQKETSVL GPAEAHYAFM LDSCFTSPPP
  1381  EENPLVGFAS IGDSSLYIIL KKLLDFILKT GGGFQRVRTH LYGSLLYYLQ IAQRPDEPDT
  1441  LEAAKKTMWE RLTAPEDVFS KLQRENIAII ESYGAALMEV VCRDACDGHE IGRMLALALL
  1501  DRIVSVDKQQ QWLLYLSNSG YLKVLVDSLV EDDRTLQSLL TPQPPLLKAL YTYESKMAFL
  1561  TRVAKIQQGA LELLRSGVIV RLAQCQVYDM RPETDPQSMF GMRDPPMFIP TPVDRYRQIL
  1621  LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI SHSDTIQAIL RCQDVSAGSL QELALLTGII
  1681  SKAALPGILS ELDVDVNEGS LMELQGHIGR FQRQCLGLLS RFGGSDRLRQ FKFQDDNVEG
  1741  DKVSKKDEIE LAMQQICANV MEYCQSLMLQ SSPTFQHAVC LFTPSLSETV NRDGPRQDTQ
  1801  APVVPYWRLP GLGIIIYLLK QSANDFFSYY DSHRQSVSKL QNVEQLPPDE IKELCQSVMP
  1861  AGVDKISTAQ KYVLARRRLV KVINNRAKLL SLCSFIIETC LFILWRHLEY YLLHCMPTDS
  1921  QDSLFASRTL FKSRRLQDSF ASETNLDFRS GLAIVSQHDL DQLQADAINA FGESLQKKLL
  1981  DIEGLYSKVR SRYSFIQALV RRIRGLLRIS RN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP205 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

thymus: 20 nTPM
tonsil: 16 nTPM
parathyroid gland: 14 nTPM
lymph node: 14 nTPM
retina: 14 nTPM
appendix: 12 nTPM

Single-cell type

sertoli cells: 106 nCPM
monocyte progenitors: 97 nCPM
erythrocyte progenitors: 81 nCPM
adrenal medulla cells: 75 nCPM
neutrophil progenitors: 61 nCPM
thyrotrophs: 59 nCPM

Immune cell

intermediate monocyte: 3.1 nTPM
myeloid DC: 3 nTPM
memory CD4 T-cell: 2.9 nTPM
NK-cell: 2.9 nTPM
T-reg: 2.9 nTPM
MAIT T-cell: 2.8 nTPM

Brain region

cerebellum: 23 nTPM
white matter: 18 nTPM
choroid plexus: 17 nTPM
thalamus: 16 nTPM
pons: 16 nTPM
basal ganglia: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP205.

Disease | AllUniProt

Conditions NUP205 is implicated in, by any mechanism.

Nephrotic syndrome 13 (NPHS13) MIM:616893

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 697 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Nephrotic syndrome, type 13

Disease | ImmuneIEDB

Conditions an epitope on NUP205 was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 1.35
DepMap mean gene effect: -1.19
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of nuclear pore

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoporin Nup186/Nup192/Nup205
Nuclear pore complex scaffold, nucleoporins 186/192/205

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP205 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP205 as an antibody target. Whether an autoantibody or antibody against NUP205 could matter depends on whether native NUP205 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP205 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP205 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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