Seroatlas · Human Serome Atlas

TMEM179B

Transmembrane protein 179B

Also known as: T179B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7N9
Gene: TMEM179B
Ensembl: ENSG00000185475
Chromosome: 11
Canonical length: 219 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

219 residues, UniProt reviewed canonical sequence.

>Q7Z7N9|TMEM179B
     1  MALSWLQRVE LALFAAAFLC GAVAAAAMTR TQGSFSGRCP LYGVATLNGS SLALSRPSAP
    61  SLCYFVAGAS GLLALYCLLL LLFWIYSSCI EDSHRGAIGL RIALAISAIA VFLVLVSACI
   121  LRFGTRSLCN SIISLNTTIS CSEAQKIPWT PPGTALQFYS NLHNAETSSW VNLVLWCVVL
   181  VLQVVQWKSE ATPYRPLERG DPEWSSETDA LVGSRLSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM179B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 81 nTPM
epididymis: 67 nTPM
liver: 59 nTPM
adrenal gland: 55 nTPM
salivary gland: 54 nTPM
pancreas: 54 nTPM

Single-cell type

syncytiotrophoblasts: 223 nCPM
extravillous trophoblasts: 218 nCPM
cytotrophoblasts: 214 nCPM
migrating cytotrophoblasts: 175 nCPM
enterocytes: 174 nCPM
esophageal suprabasal cells: 173 nCPM

Immune cell

plasmacytoid DC: 367 nTPM
eosinophil: 334 nTPM
non-classical monocyte: 307 nTPM
intermediate monocyte: 305 nTPM
basophil: 304 nTPM
classical monocyte: 301 nTPM

Brain region

choroid plexus: 39 nTPM
white matter: 27 nTPM
medulla oblongata: 26 nTPM
basal ganglia: 23 nTPM
pons: 22 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 179/179B
Transmembrane protein 179/179B Claudin domain
Transmembrane protein 179B

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM179B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CANX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM179B as an antibody target. Whether an autoantibody or antibody against TMEM179B could matter depends on whether native TMEM179B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM179B is annotated at the cell surface, where native TMEM179B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM179B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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