Seroatlas · Human Serome Atlas

TMEM178B

Transmembrane protein 178B

Also known as: DKFZp547G036, T178B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BS89
Gene
TMEM178B
Ensembl
ENSG00000261115
Chromosome
7
Canonical length
294 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>H3BS89|TMEM178B
     1  MAAGRLLLYT GLSLALCALG MLAVAICSDH WYETDARKHR DRCKAFNTRR VDPGFIYNNN
    61  NNLPLRASRS RLDRWEGKLL RARNRRQLFA MSPADECSRQ YNSTNMGLWR KCHRQGFDPE
   121  IAALIRKGEI ERCTYIKYHY SSATIPRNLT FNITKTIRQD EWHALHLRRM TAGFMGMAVA
   181  IILFGWIIGV LGCCWDRGLM QYVAGLLFLM GGTFCIISLC TCVAGINFEL SRYPRYLYGL
   241  PDDISHGYGW SMFCAWGGLG LTLISGFFCT LAPSVQPVPR TNYPKSRPEN GTVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM178B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 11 nTPM
  • tongue: 11 nTPM
  • cerebral cortex: 11 nTPM
  • heart muscle: 10 nTPM
  • thyroid gland: 7.9 nTPM
  • basal ganglia: 6.1 nTPM

Single-cell type

  • corticotrophs: 1,489 nCPM
  • lactotrophs: 950 nCPM
  • thyrotrophs: 796 nCPM
  • cardiomyocytes: 750 nCPM
  • brain inhibitory neurons: 738 nCPM
  • retinal amacrine cells: 728 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 37 nTPM
  • midbrain: 35 nTPM
  • hippocampal formation: 35 nTPM
  • pons: 35 nTPM
  • hypothalamus: 33 nTPM
  • thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.95
gnomAD missense Z
2.32
DepMap mean gene effect
0.06
DepMap dependency class
none

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM178B as an antibody target. Whether an autoantibody or antibody against TMEM178B could matter depends on whether native TMEM178B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM178B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM178B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM178B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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