Seroatlas · Human Serome Atlas

TMEM176A

Transmembrane protein 176A

Also known as: HCA112, MS4B1, T176A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HP8
Gene: TMEM176A
Ensembl: ENSG00000002933
Chromosome: 7
Canonical length: 235 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to act upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q96HP8|TMEM176A
     1  MGTADSDEMA PEAPQHTHID VHIHQESALA KLLLTCCSAL RPRATQARGS SRLLVASWVM
    61  QIVLGILSAV LGGFFYIRDY TLLVTSGAAI WTGAVAVLAG AAAFIYEKRG GTYWALLRTL
   121  LTLAAFSTAI AALKLWNEDF RYGYSYYNSA CRISSSSDWN TPAPTQSPEE VRRLHLCTSF
   181  MDMLKALFRT LQAMLLGVWI LLLLASLTPL WLYCWRMFPT KGKRDQKEML EVSGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM176A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 1,278 nTPM

Expression across tissuesHPA

Tissue

liver: 1,278 nTPM
kidney: 352 nTPM
small intestine: 191 nTPM
rectum: 142 nTPM
colon: 135 nTPM
gallbladder: 122 nTPM

Single-cell type

enterocytes: 1,156 nCPM
hepatocytes: 1,030 nCPM
epididymal efferent duct absorptive cells: 462 nCPM
colonocytes: 344 nCPM
tuft cells: 311 nCPM
enteric transient amplifying cells: 228 nCPM

Immune cell

classical monocyte: 147 nTPM
intermediate monocyte: 99 nTPM
total PBMC: 53 nTPM
non-classical monocyte: 46 nTPM
myeloid DC: 31 nTPM
eosinophil: 13 nTPM

Brain region

medulla oblongata: 65 nTPM
white matter: 63 nTPM
spinal cord: 61 nTPM
midbrain: 50 nTPM
hypothalamus: 49 nTPM
pons: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0.01
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of dendritic cell differentiation

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM176A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MCOLN2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM176A as an antibody target. Whether an autoantibody or antibody against TMEM176A could matter depends on whether native TMEM176A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM176A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM176A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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