Seroatlas · Human Serome Atlas

MCOLN2

Mucolipin-2

Also known as: FLJ36691, MCLN2_HUMAN, TRP-ML2, TRPML2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZK6
Gene
MCOLN2
Ensembl
ENSG00000153898
Chromosome
1
Canonical length
566 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure
Homooligomer

OverviewNCBI Gene

Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q8IZK6|MCOLN2
     1  MARQPYRFPQ ARIPERGSGV FRLTVRNAMA HRDSEMKEEC LREDLKFYFM SPCEKYRARR
    61  QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA FKHLFLKGYS GTDEDDYSCS
   121  VYTQEDAYES IFFAINQYHQ LKDITLGTLG YGENEDNRIG LKVCKQHYKK GTMFPSNETL
   181  NIDNDVELDC VQLDLQDLSK KPPDWKNSSF FRLEFYRLLQ VEISFHLKGI DLQTIHSREL
   241  PDCYVFQNTI IFDNKAHSGK IKIYFDSDAK IEECKDLNIF GSTQKNAQYV LVFDAFVIVI
   301  CLASLILCTR SIVLALRLRK RFLNFFLEKY KRPVCDTDQW EFINGWYVLV IISDLMTIIG
   361  SILKMEIKAK NLTNYDLCSI FLGTSTLLVW VGVIRYLGYF QAYNVLILTM QASLPKVLRF
   421  CACAGMIYLG YTFCGWIVLG PYHDKFENLN TVAECLFSLV NGDDMFATFA QIQQKSILVW
   481  LFSRLYLYSF ISLFIYMILS LFIALITDSY DTIKKFQQNG FPETDLQEFL KECSSKEEYQ
   541  KESSAFLSCI CCRRRKRSDD HLIPIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCOLN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 14 nTPM
  • tonsil: 12 nTPM
  • lymph node: 12 nTPM
  • colon: 9.5 nTPM
  • adrenal gland: 8.5 nTPM
  • spleen: 6.2 nTPM

Single-cell type

  • cdc: 247 nCPM
  • pdcs: 165 nCPM
  • b-cells: 77 nCPM
  • adrenal cortex cells: 69 nCPM
  • endometrial luminal cells: 66 nCPM
  • t-cells: 66 nCPM

Immune cell

  • plasmacytoid DC: 30 nTPM
  • memory B-cell: 10 nTPM
  • memory CD8 T-cell: 8.8 nTPM
  • myeloid DC: 7.1 nTPM
  • gdT-cell: 5.9 nTPM
  • memory CD4 T-cell: 5 nTPM

Brain region

  • cerebellum: 2.5 nTPM
  • choroid plexus: 2.5 nTPM
  • medulla oblongata: 2.2 nTPM
  • white matter: 2.2 nTPM
  • thalamus: 2 nTPM
  • cerebral cortex: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCOLN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCOLN2 as an antibody target. Whether an autoantibody or antibody against MCOLN2 could matter depends on whether native MCOLN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCOLN2 is annotated at the cell surface, where native MCOLN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MCOLN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCOLN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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