Seroatlas · Human Serome Atlas

TMEM170B

Transmembrane protein 170B

Also known as: T170B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T4T1
Gene: TMEM170B
Ensembl: ENSG00000205269
Chromosome: 6
Canonical length: 132 aa
Protein class: Predicted membrane proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q5T4T1|TMEM170B
     1  MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH GAAGVLMFVM
    61  LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA GKNMAPLEAL VWGVGQTVLT
   121  LIISFSRILA TL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM170B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 24 nTPM
cerebral cortex: 11 nTPM
retina: 8.8 nTPM
liver: 8.1 nTPM
cerebellum: 7.6 nTPM
tongue: 6.8 nTPM

Single-cell type

neutrophil progenitors: 275 nCPM
monocyte progenitors: 176 nCPM
monocytes: 173 nCPM
neutrophils: 173 nCPM
pituitary stem cells: 69 nCPM
kupffer cells: 66 nCPM

Immune cell

basophil: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM
classical monocyte: 0.8 nTPM
eosinophil: 0.5 nTPM
myeloid DC: 0.5 nTPM
intermediate monocyte: 0.4 nTPM

Brain region

cerebral cortex: 28 nTPM
pons: 25 nTPM
basal ganglia: 24 nTPM
cerebellum: 24 nTPM
hippocampal formation: 23 nTPM
midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.79
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM170B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTNNB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM170B as an antibody target. Whether an autoantibody or antibody against TMEM170B could matter depends on whether native TMEM170B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM170B is annotated at the cell surface, where native TMEM170B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM170B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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