Seroatlas · Human Serome Atlas

TMEM109

Voltage-gated monoatomic cation channel TMEM109

Also known as: MGC5508, TM109_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVC6
Gene: TMEM109
Ensembl: ENSG00000110108
Chromosome: 11
Canonical length: 243 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nuclear membrane,Endoplasmic reticulum,Vesicles,Actin filaments
Quaternary structure: Homooligomer

OverviewNCBI Gene

Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within cellular response to gamma radiation and negative regulation of programmed cell death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q9BVC6|TMEM109
     1  MAASSISSPW GKHVFKAILM VLVALILLHS ALAQSRRDFA PPGQQKREAP VDVLTQIGRS
    61  VRGTLDAWIG PETMHLVSES SSQVLWAISS AISVAFFALS GIAAQLLNAL GLAGDYLAQG
   121  LKLSPGQVQT FLLWGAGALV VYWLLSLLLG LVLALLGRIL WGLKLVIFLA GFVALMRSVP
   181  DPSTRALLLL ALLILYALLS RLTGSRASGA QLEAKVRGLE RQVEELRWRQ RRAAKGARSV
   241  EEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM109 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 119 nTPM
endometrium: 96 nTPM
esophagus: 95 nTPM
skeletal muscle: 93 nTPM
adipose tissue: 83 nTPM
heart muscle: 82 nTPM

Single-cell type

esophageal apical cells: 182 nCPM
cytotrophoblasts: 146 nCPM
extravillous trophoblasts: 141 nCPM
esophageal basal cells: 133 nCPM
migrating cytotrophoblasts: 126 nCPM
pdcs: 116 nCPM

Immune cell

plasmacytoid DC: 471 nTPM
myeloid DC: 228 nTPM
MAIT T-cell: 194 nTPM
gdT-cell: 189 nTPM
memory CD8 T-cell: 161 nTPM
naive B-cell: 141 nTPM

Brain region

choroid plexus: 74 nTPM
medulla oblongata: 42 nTPM
spinal cord: 40 nTPM
thalamus: 40 nTPM
pons: 39 nTPM
midbrain: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

voltage-gated monoatomic cation channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Negative regulator of p53/TP53
Transmembrane protein 109

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM109 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CRYAB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM109 as an antibody target. Whether an autoantibody or antibody against TMEM109 could matter depends on whether native TMEM109 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM109 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM109 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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