Seroatlas · Human Serome Atlas

TMEM106C

Transmembrane protein 106C

Also known as: MGC5576, T106C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVX2
Gene: TMEM106C
Ensembl: ENSG00000134291
Chromosome: 12
Canonical length: 250 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q9BVX2|TMEM106C
     1  MGSQHSAAAR PSSCRRKQED DRDGLLAERE QEEAIAQFPY VEFTGRDSIT CLTCQGTGYI
    61  PTEQVNELVA LIPHSDQRLR PQRTKQYVLL SILLCLLASG LVVFFLFPHS VLVDDDGIKV
   121  VKVTFNKQDS LVILTIMATL KIRNSNFYTV AVTSLSSQIQ YMNTVVSTYV TTNVSLIPPR
   181  SEQLVNFTGK AEMGGPFSYV YFFCTVPEIL VHNIVIFMRT SVKISYIGLM TQSSLETHHY
   241  VDCGGNSTAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM106C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 165 nTPM
parathyroid gland: 137 nTPM
rectum: 136 nTPM
colon: 129 nTPM
epididymis: 128 nTPM
small intestine: 113 nTPM

Single-cell type

epididymal clear cells: 347 nCPM
enterocytes: 333 nCPM
enteric transient amplifying cells: 254 nCPM
colonocytes: 210 nCPM
paneth cells: 209 nCPM
enteric stem cells: 171 nCPM

Immune cell

T-reg: 67 nTPM
MAIT T-cell: 55 nTPM
memory CD8 T-cell: 47 nTPM
gdT-cell: 45 nTPM
naive CD8 T-cell: 44 nTPM
memory CD4 T-cell: 43 nTPM

Brain region

choroid plexus: 66 nTPM
hypothalamus: 37 nTPM
hippocampal formation: 30 nTPM
cerebellum: 27 nTPM
basal ganglia: 25 nTPM
cerebral cortex: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM106C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM106C as an antibody target. Whether an autoantibody or antibody against TMEM106C could matter depends on whether native TMEM106C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM106C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM106C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...