Seroatlas · Human Serome Atlas

TMEM106A

Transmembrane protein 106A

Also known as: MGC20235, T106A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A25
Gene: TMEM106A
Ensembl: ENSG00000184988
Chromosome: 17
Canonical length: 262 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and positive regulation of nitric oxide metabolic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q96A25|TMEM106A
     1  MGKTFSQLGS WREDENKSIL SSKPAIGSKA VNYSSTGSSK SFCSCVPCEG TADASFVTCP
    61  TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV LICLVTSSFI VFFLFPRSVI
   121  VQPAGLNSST VAFDEADIYL NITNILNISN GNYYPIMVTQ LTLEVLHLSL VVGQVSNNLL
   181  LHIGPLASEQ MFYAVATKIR DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ
   241  SYEYVDCRGN ASVPHQLTPH PP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM106A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

kidney: 20 nTPM
appendix: 9.6 nTPM
placenta: 9.5 nTPM
spleen: 9.1 nTPM
smooth muscle: 8.3 nTPM
lymph node: 6.5 nTPM

Single-cell type

hofbauer cells: 108 nCPM
proximal tubule cells: 95 nCPM
microglia: 69 nCPM
macrophages: 66 nCPM
kupffer cells: 62 nCPM
monocytes: 52 nCPM

Immune cell

basophil: 27 nTPM
plasmacytoid DC: 6 nTPM
eosinophil: 5.7 nTPM
intermediate monocyte: 5.6 nTPM
classical monocyte: 5.1 nTPM
myeloid DC: 4.2 nTPM

Brain region

thalamus: 19 nTPM
medulla oblongata: 19 nTPM
white matter: 14 nTPM
pons: 14 nTPM
cerebral cortex: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM106A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMEM106C

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM106A as an antibody target. Whether an autoantibody or antibody against TMEM106A could matter depends on whether native TMEM106A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM106A is annotated at the cell surface, where native TMEM106A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM106A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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