Seroatlas · Human Serome Atlas

TMED8

Protein TMED8

Also known as: FAM15B, TMED8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PL24
Gene: TMED8
Ensembl: ENSG00000100580
Chromosome: 14
Canonical length: 325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

No narrative summary is available for TMED8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q6PL24|TMED8
     1  MSDLQAAEGP GSWSPTARPG SAGGVGDCQG VEGSQAAASE NEDLENKDTS LLASATDPEP
    61  CSSPHRPQMV SPVSKDATED LRKATGPLEA QALVKQDLLP ADQAQVLNEM AKYQVPQRSG
   121  DIVMIQSEHT GAIDVLSADL ESADLLGDHR KVSPPLMAPP CIWTFAKVKE FKSKLGKEKN
   181  SRLVVKRGEV VTIRVPTHPE GKRVCWEFAT DDYDIGFGVY FDWTPVTSTD ITVQVSDSSD
   241  DEDEEEEEEE EIEEPVPAGD VERGSRSSLR GRYGEVMPVY RRDSHRDVQA GSHDYPGEGI
   301  YLLKFDNSYS LLRNKTLYFH IYYTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMED8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

retina: 22 nTPM
tonsil: 18 nTPM
lymph node: 16 nTPM
hypothalamus: 11 nTPM
parathyroid gland: 10 nTPM
thyroid gland: 10 nTPM

Single-cell type

neutrophils: 230 nCPM
cone photoreceptor cells: 170 nCPM
sertoli cells: 121 nCPM
monocyte progenitors: 107 nCPM
pancreatic islet cells: 106 nCPM
neutrophil progenitors: 105 nCPM

Immune cell

basophil: 2.3 nTPM
eosinophil: 2.2 nTPM
memory B-cell: 2.1 nTPM
naive B-cell: 2.1 nTPM
neutrophil: 1 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

hypothalamus: 47 nTPM
pons: 36 nTPM
midbrain: 34 nTPM
thalamus: 33 nTPM
basal ganglia: 32 nTPM
medulla oblongata: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.09
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of TMED8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SEC61B

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMED8 as an antibody target. Whether an autoantibody or antibody against TMED8 could matter depends on whether native TMED8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMED8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMED8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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