Seroatlas · Human Serome Atlas

TMDD1

Transmembrane and death domain protein 1

Also known as: C12orf81, hCG1648055, TMDD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPE3
Gene: TMDD1
Ensembl: ENSG00000284730
Chromosome: 12
Canonical length: 317 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>P0DPE3|TMDD1
     1  MAARTLASAL VLTLWVWALA PAGAVDAMGP HAAVRLAELL TPEECGHFRS LLEAPEPDVE
    61  AELSRLSEDR LARPEPLNTT SGSPSRRRRR EAAEDPAGRV AGPGEVSDGC REALAAWLAP
   121  QAASLSWDRL ARALRRSGRP DVARELGKNL HQQATLQLRK FGQRFLPRPG AAARVPFAPA
   181  PRPRRAAVPA PDWDALQLIV ERLPQPLYER SPMGWAGPLA LGLLTGFVGA LGTGALVVLL
   241  TLWITGGDGD RASPGSPGPL ATVQGWWETK LLLPKERRAP PGAWAADGPD SPSPHSALAL
   301  SCKMGAQSWG SGALDGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
liver: 1.4 nTPM
adipose tissue: 0.6 nTPM
salivary gland: 0.6 nTPM
breast: 0.5 nTPM
kidney: 0.5 nTPM

Single-cell type

early spermatids: 33 nCPM
late primary spermatocytes: 19 nCPM
late spermatids: 13 nCPM
epididymal principal cells: 13 nCPM
breast lactating cells: 6.8 nCPM
hepatocytes: 4.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2.4 nTPM
cerebral cortex: 2.1 nTPM
basal ganglia: 1.9 nTPM
hippocampal formation: 1.8 nTPM
amygdala: 1.7 nTPM
cerebellum: 1.7 nTPM

OntologyGO

Biological processes

signal transduction

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Death domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMDD1 as an antibody target. Whether an autoantibody or antibody against TMDD1 could matter depends on whether native TMDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMDD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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