Seroatlas · Human Serome Atlas

TKTL2

Transketolase-like protein 2

Also known as: DKFZP434L1717, FLJ32975, TKTL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0I9
Gene: TKTL2
Ensembl: ENSG00000151005
Chromosome: 4
Canonical length: 626 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q9H0I9|TKTL2
     1  MMANDAKPDV KTVQVLRDTA NRLRIHSIRA TCASGSGQLT SCCSAAEVVS VLFFHTMKYK
    61  QTDPEHPDND RFILSRGHAA PILYAAWVEV GDISESDLLN LRKLHSDLER HPTPRLPFVD
   121  VATGSLGQGL GTACGMAYTG KYLDKASYRV FCLMGDGESS EGSVWEAFAF ASHYNLDNLV
   181  AVFDVNRLGQ SGPAPLEHGA DIYQNCCEAF GWNTYLVDGH DVEALCQAFW QASQVKNKPT
   241  AIVAKTFKGR GIPNIEDAEN WHGKPVPKER ADAIVKLIES QIQTNENLIP KSPVEDSPQI
   301  SITDIKMTSP PAYKVGDKIA TQKTYGLALA KLGRANERVI VLSGDTMNST FSEIFRKEHP
   361  ERFIECIIAE QNMVSVALGC ATRGRTIAFA GAFAAFFTRA FDQLRMGAIS QANINLIGSH
   421  CGVSTGEDGV SQMALEDLAM FRSIPNCTVF YPSDAISTEH AIYLAANTKG MCFIRTSQPE
   481  TAVIYTPQEN FEIGQAKVVR HGVNDKVTVI GAGVTLHEAL EAADHLSQQG ISVRVIDPFT
   541  IKPLDAATII SSAKATGGRV ITVEDHYREG GIGEAVCAAV SREPDILVHQ LAVSGVPQRG
   601  KTSELLDMFG ISTRHIIAAV TLTLMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TKTL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.19
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

testis: 54 nTPM
bone marrow: 0.1 nTPM
retina: 0.1 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 401 nCPM
early spermatids: 56 nCPM
late spermatids: 54 nCPM
early primary spermatocytes: 37 nCPM
peritubular myoid cells: 1.9 nCPM
differentiating spermatogonia: 1.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebral cortex: 0.2 nTPM
medulla oblongata: 0.2 nTPM
pons: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TKTL2 as an antibody target. Whether an autoantibody or antibody against TKTL2 could matter depends on whether native TKTL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TKTL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TKTL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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