Seroatlas · Human Serome Atlas

TIGIT

T-cell immunoreceptor with Ig and ITIM domains

Also known as: DKFZp667A205, FLJ39873, TIGIT_HUMAN, VSIG9, VSTM3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495A1
Gene: TIGIT
Ensembl: ENSG00000181847
Chromosome: 3
Canonical length: 244 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q495A1|TIGIT
     1  MRWCLLLIWA QGLRQAPLAS GMMTGTIETT GNISAEKGGS IILQCHLSST TAQVTQVNWE
    61  QQDQLLAICN ADLGWHISPS FKDRVAPGPG LGLTLQSLTV NDTGEYFCIY HTYPDGTYTG
   121  RIFLEVLESS VAEHGARFQI PLLGAMAATL VVICTAVIVV VALTRKKKAL RIHSVEGDLR
   181  RKSAGQEEWS PSAPSPPGSC VQAEAAPAGL CGEQRGEDCA ELHDYFNVLS YRSLGNCSFF
   241  TETG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGIT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

lymph node: 36 nTPM
tonsil: 19 nTPM
spleen: 14 nTPM
appendix: 11 nTPM
thymus: 8.5 nTPM
small intestine: 4.8 nTPM

Single-cell type

t-cells: 96 nCPM
nk-cells: 59 nCPM
epicardial cells: 14 nCPM
plasma cells: 9.7 nCPM
cardiomyocytes: 8.2 nCPM
endometrial stromal cells: 4.7 nCPM

Immune cell

T-reg: 196 nTPM
memory CD8 T-cell: 90 nTPM
memory CD4 T-cell: 49 nTPM
naive CD8 T-cell: 40 nTPM
gdT-cell: 30 nTPM
total PBMC: 22 nTPM

Brain region

thalamus: 3.6 nTPM
cerebral cortex: 3.5 nTPM
white matter: 3.4 nTPM
medulla oblongata: 3.1 nTPM
pons: 3 nTPM
basal ganglia: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0.02
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin domain subtype
Immunoglobulin-like domain
Immunoglobulin V-set domain
Immunoglobulin-like fold
Immunoglobulin-like domain superfamily
Immunoglobulin V-set domain
T-cell immunoglobulin and ITIM domain receptor

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIGIT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGIT as an antibody target. Whether an autoantibody or antibody against TIGIT could matter depends on whether native TIGIT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGIT is annotated at the cell surface, where native TIGIT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TIGIT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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