Seroatlas · Human Serome Atlas

TIGD7

Tigger transposable element-derived protein 7

Also known as: Sancho, TIGD7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NT04
Gene: TIGD7
Ensembl: ENSG00000140993
Chromosome: 16
Canonical length: 549 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>Q6NT04|TIGD7
     1  MNKRGKYTTL NLEEKMKVLS RIEAGRSLKS VMDEFGISKS TFYDIKKNKK LILDFVLKQD
    61  MPLVGAEKRK RTTGAKYGDV DDAVYMWYQQ KRSAGVPVRG VELQAAAERF ARCFGRTDFK
   121  ASTGWLFRFR NRHAIGNRKG CGEQVLSSVS ENVEPFRQKL SMIIKEEKLC LAQLYSGDET
   181  DLFWKSMPEN SQASRKDICL PGKKINKERL SAFLCANADG THKLKSIIIG KSKLPKSVKE
   241  DTSTLPVIYK PSKDVWFTRE LFSEWFFQNF VPEVRHFQLN VLRFHDEDVR ALLLLDSCPA
   301  HPSSESLTSE DGRIKCMFFP HNTSTLIQPM NQGVILSCKR LYRWKQLEES LVIFEESDDE
   361  QEKGDKGVSK IKIYNIKSAI FNWAKSWEEV KQITIANAWE NLLYKKEPEY DFQGLEHGDY
   421  REILEKCGEL ETKLDDDRVW LNGDEEKGCL LKTKGGITKE VVQKGGEAEK QTAEFKLSAV
   481  RESLDYLLDF VDATPEFQRF HFTLKEMQQE IVKKQFQSKI HSRIGSFLKP RPHNIKDSFS
   541  GPSTSGSNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

ovary: 9.5 nTPM
choroid plexus: 9.3 nTPM
testis: 8.6 nTPM
pituitary gland: 8.4 nTPM
retina: 7.6 nTPM
cerebellum: 7 nTPM

Single-cell type

cardiomyocytes: 66 nCPM
choroid plexus epithelial cells: 46 nCPM
somatotrophs: 29 nCPM
adipocytes: 26 nCPM
oligodendrocyte progenitor cells: 26 nCPM
lactotrophs: 23 nCPM

Immune cell

eosinophil: 3.6 nTPM
MAIT T-cell: 3.1 nTPM
non-classical monocyte: 3.1 nTPM
naive B-cell: 3 nTPM
naive CD4 T-cell: 2.7 nTPM
NK-cell: 2.7 nTPM

Brain region

choroid plexus: 9.6 nTPM
cerebellum: 6.7 nTPM
white matter: 6.1 nTPM
hypothalamus: 6 nTPM
midbrain: 5.9 nTPM
pons: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGD7 as an antibody target. Whether an autoantibody or antibody against TIGD7 could matter depends on whether native TIGD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIGD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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