Seroatlas · Human Serome Atlas

TIGD6

Tigger transposable element-derived protein 6

Also known as: DKFZp761E2110, TIGD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RP2
Gene: TIGD6
Ensembl: ENSG00000164296
Chromosome: 5
Canonical length: 521 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Actin filaments

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

521 residues, UniProt reviewed canonical sequence.

>Q17RP2|TIGD6
     1  MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE
    61  ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS
   121  VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE
   181  TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN
   241  IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV
   301  GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW
   361  WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF
   421  VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL
   481  STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 11 nTPM
epididymis: 4.8 nTPM
breast: 4.4 nTPM
testis: 3.9 nTPM
prostate: 3.8 nTPM
ovary: 3.7 nTPM

Single-cell type

adrenal medulla cells: 21 nCPM
early primary spermatocytes: 19 nCPM
epididymal principal cells: 17 nCPM
epicardial cells: 14 nCPM
late primary spermatocytes: 12 nCPM
adrenal cortex cells: 11 nCPM

Immune cell

naive CD4 T-cell: 4.2 nTPM
NK-cell: 3.4 nTPM
naive CD8 T-cell: 2.7 nTPM
intermediate monocyte: 2.3 nTPM
classical monocyte: 2.2 nTPM
T-reg: 2.2 nTPM

Brain region

cerebellum: 4.9 nTPM
choroid plexus: 4.9 nTPM
white matter: 4.6 nTPM
basal ganglia: 4.4 nTPM
hypothalamus: 4.3 nTPM
midbrain: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGD6 as an antibody target. Whether an autoantibody or antibody against TIGD6 could matter depends on whether native TIGD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIGD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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