Seroatlas · Human Serome Atlas

TIGD4

Tigger transposable element-derived protein 4

Also known as: TIGD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IY51
Gene: TIGD4
Ensembl: ENSG00000169989
Chromosome: 4
Canonical length: 512 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

512 residues, UniProt reviewed canonical sequence.

>Q8IY51|TIGD4
     1  MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK NSLSSIMKNK
    61  DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC LNVPVNGPML RLKANDFAQK
   121  LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE ATGVPVDPST VWYQNVLPYY LNDYHPKNVF
   181  NIKETGLLYR MLPTNTFAFK GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH
   241  CFKGLKSLPV CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK
   301  SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF SLLDAVDTLH
   361  LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL VADALGAGVE FPEGLSIEEY
   421  AALDDDLETC EAAPNGDSIC TKESKSDETG FYTSDEEDDD GSPGTELPLP SKSEAITALD
   481  TLKKFLRSQD MNDGLQNSLA DLENFINSLS PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

retina: 20 nTPM
testis: 4.6 nTPM
fallopian tube: 1.9 nTPM
parathyroid gland: 1.4 nTPM
epididymis: 1.1 nTPM
pituitary gland: 1.1 nTPM

Single-cell type

late primary spermatocytes: 116 nCPM
early spermatids: 107 nCPM
rod photoreceptor cells: 66 nCPM
ependymal cells: 53 nCPM
microglia: 44 nCPM
pituitary stem cells: 38 nCPM

Immune cell

NK-cell: 0.4 nTPM
neutrophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 3.3 nTPM
medulla oblongata: 3 nTPM
midbrain: 3 nTPM
spinal cord: 2.7 nTPM
hypothalamus: 2.3 nTPM
thalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGD4 as an antibody target. Whether an autoantibody or antibody against TIGD4 could matter depends on whether native TIGD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIGD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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