Seroatlas · Human Serome Atlas

TIGD3

Tigger transposable element-derived protein 3

Also known as: TIGD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6B0B8
Gene: TIGD3
Ensembl: ENSG00000173825
Chromosome: 11
Canonical length: 471 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q6B0B8|TIGD3
     1  MELSSKKKLH ALSLAEKIQV LELLDESKMS QSEVARRFQV SQPQISRICK NKEKLLADWC
    61  SGTANRERKR KRESKYSGID EALLCWYHIA RAKAWDVTGP MLLHKAKELA DIMGQDFVPS
   121  IGWLVRWKRR NNVGFGARHV LAPSFPPEPP PPGLTSQAQL PLSLKDFSPE DVFGCAELPL
   181  LYRAVPGSFG ACDQVQVLLC ANSRGTEKRR VLLGGLQAAP RCFFGIRSEA LPASYHPDLG
   241  IPWLEWLAQF DRDMGQQGRQ VALLLAARVV EELAGLPGLY HVKLLPLAAS STTPPLPSSV
   301  VRAFKAHYRH RLLGKLAAIQ SERDGTSLAE AGAGITVLDA LHVASAAWAK VPPQLIFSSF
   361  IQEGLAPGKT PPSSHKTSEM PPVPGGLSLE EFSRFVDLEG EEPRSGVCKE EIGTEDEKGD
   421  REGAFEPLPT KADALRALGT LRRWFECNST SPELFEKFYD CEEEVERLCC L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5 nTPM
testis: 4.8 nTPM
small intestine: 2.4 nTPM
cerebral cortex: 2 nTPM
basal ganglia: 1.5 nTPM
hippocampal formation: 1.2 nTPM

Single-cell type

early primary spermatocytes: 43 nCPM
pdcs: 11 nCPM
enterocytes: 9.5 nCPM
late primary spermatocytes: 8.3 nCPM
granulosa cells: 7.3 nCPM
differentiating spermatogonia: 5.9 nCPM

Immune cell

neutrophil: 18 nTPM
eosinophil: 11 nTPM
basophil: 7.8 nTPM
non-classical monocyte: 1.5 nTPM
plasmacytoid DC: 1.5 nTPM
myeloid DC: 1 nTPM

Brain region

cerebellum: 4.9 nTPM
cerebral cortex: 4.2 nTPM
basal ganglia: 3.4 nTPM
hippocampal formation: 2.3 nTPM
midbrain: 2.3 nTPM
white matter: 2.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TIGD3.

Disease | ImmuneIEDB

Conditions an epitope on TIGD3 was assayed in.

hepatocellular carcinoma T cell
stomach cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGD3 as an antibody target. Whether an autoantibody or antibody against TIGD3 could matter depends on whether native TIGD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIGD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...