TIGD2
Tigger transposable element-derived protein 2
Also known as: TIGD2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q4W5G0
- Gene
- TIGD2
- Ensembl
- ENSG00000180346
- Chromosome
- 4
- Canonical length
- 525 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear bodies
OverviewNCBI Gene
The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
525 residues, UniProt reviewed canonical sequence.
>Q4W5G0|TIGD2
1 MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE RIINYANSSD
61 PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQAKFFF DALGMEGDFN
121 ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AAREFCGSFQ EFVEKENLQP EQIYGADQTG
181 LFWKCLPSRT LTLETDQSTS GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT
241 DLSNLPVTYY SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE
301 EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG NDPKIFWKNL
361 TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI DEGAILAANL ATVLQNTEEC
421 EHVDIENIDQ WFDSRSSDSS CQVLTDSESA EDQTKAAEQK PSSKSRKTEL NPEKHISHKA
481 ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRKKQKIQ NNKNHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TIGD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- liver: 21 nTPM
- retina: 11 nTPM
- salivary gland: 9.5 nTPM
- breast: 8.4 nTPM
- placenta: 7.4 nTPM
- duodenum: 6.2 nTPM
Single-cell type
- syncytiotrophoblasts: 49 nCPM
- hepatocytes: 24 nCPM
- breast lactating cells: 19 nCPM
- cytotrophoblasts: 19 nCPM
- oocytes: 18 nCPM
- extravillous trophoblasts: 14 nCPM
Immune cell
- basophil: 12 nTPM
- NK-cell: 2.2 nTPM
- gdT-cell: 1.9 nTPM
- intermediate monocyte: 1.9 nTPM
- myeloid DC: 1.5 nTPM
- memory CD8 T-cell: 1.4 nTPM
Brain region
- cerebellum: 10 nTPM
- choroid plexus: 8.6 nTPM
- midbrain: 5.5 nTPM
- hypothalamus: 5.2 nTPM
- white matter: 4.9 nTPM
- pons: 4.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.49
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TIGD2 as an antibody target. Whether an autoantibody or antibody against TIGD2 could matter depends on whether native TIGD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TIGD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TIGD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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