Seroatlas · Human Serome Atlas

TIGD1

Tigger transposable element-derived protein 1

Also known as: EEYORE, TIGD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MW7
Gene: TIGD1
Ensembl: ENSG00000221944
Chromosome: 2
Canonical length: 591 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim,Nuclear bodies,Mitotic chromosome

OverviewNCBI Gene

The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>Q96MW7|TIGD1
     1  MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV VNAKEKFLKE
    61  VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL SQSLIQNKAL TLFNSMKAER
   121  GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA QGEAASADVE AAASYPEALA KIIDEGGYTK
   181  QQIFNVDETA FYWKKMPSRT FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH
   241  SENPRALKNY TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL
   301  IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT FHKALAAMDS
   361  DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT GVWKKLIPTL IDDYEGFKTS
   421  VEEVSADVVE IAKELELEVE PEDVTELLQS HDKTLTDEEL FLMDAQRKWF LEMESTPGED
   481  AVNIVEMTTK DLEYYINLVD KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ
   541  LMRKASPMSY FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIGD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 9 nTPM

Expression across tissuesHPA

Tissue

retina: 9 nTPM
bone marrow: 5.3 nTPM
skeletal muscle: 3.7 nTPM
skin: 3.7 nTPM
lymph node: 3 nTPM
choroid plexus: 2.9 nTPM

Single-cell type

myonuclei: 92 nCPM
thymic myoid cells: 35 nCPM
tuft cells: 12 nCPM
epididymal principal cells: 11 nCPM
microglia: 11 nCPM
bergmann glia: 10 nCPM

Immune cell

naive CD4 T-cell: 3 nTPM
naive CD8 T-cell: 2.5 nTPM
neutrophil: 2.2 nTPM
naive B-cell: 2.1 nTPM
MAIT T-cell: 1.9 nTPM
memory CD4 T-cell: 1.9 nTPM

Brain region

cerebellum: 63 nTPM
white matter: 54 nTPM
cerebral cortex: 53 nTPM
basal ganglia: 50 nTPM
choroid plexus: 49 nTPM
amygdala: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

DNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIGD1 as an antibody target. Whether an autoantibody or antibody against TIGD1 could matter depends on whether native TIGD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIGD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIGD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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