Seroatlas · Human Serome Atlas

TIFAB

TRAF-interacting protein with FHA domain-containing protein B

Also known as: TIFAB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNK6
Gene: TIFAB
Ensembl: ENSG00000255833
Chromosome: 5
Canonical length: 161 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable deubiquitinase activator activity. Involved in several processes, including cochlea morphogenesis; cranial nerve development; and hard palate morphogenesis. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q6ZNK6|TIFAB
     1  MEKPLTVLRV SLYHPTLGPS AFANVPPRLQ HDTSPLLLGR GQDAHLQLQL PRLSRRHLSL
    61  EPYLEKGSAL LAFCLKALSR KGCVWVNGLT LRYLEQVPLS TVNRVSFSGI QMLVRVEEGT
   121  SLEAFVCYFH VSPSPLIYRP EAEETDEWEG ISQGQPPPGS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIFAB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

lymph node: 5.3 nTPM
tonsil: 4.6 nTPM
appendix: 3.5 nTPM
spleen: 2.5 nTPM
thymus: 1.8 nTPM
rectum: 1.4 nTPM

Single-cell type

pdcs: 30 nCPM
cdc: 27 nCPM
late spermatids: 16 nCPM
monocyte progenitors: 5.5 nCPM
late primary spermatocytes: 4.7 nCPM
macrophages: 4.7 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
myeloid DC: 4.5 nTPM
intermediate monocyte: 1.2 nTPM
classical monocyte: 0.5 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 0.2 nTPM
white matter: 0.2 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of TIFAB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TIFA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIFAB as an antibody target. Whether an autoantibody or antibody against TIFAB could matter depends on whether native TIFAB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIFAB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIFAB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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