Seroatlas · Human Serome Atlas

TICRR

Treslin

Also known as: C15orf42, FLJ41618, MGC45866, SLD3, TICRR_HUMAN, Treslin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z2Z1
Gene: TICRR
Ensembl: ENSG00000140534
Chromosome: 15
Canonical length: 1910 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables chromatin binding activity. Involved in regulation of DNA-templated DNA replication initiation. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1910 residues, UniProt reviewed canonical sequence.

>Q7Z2Z1|TICRR
     1  MACCHKVMLL LDTAGGAARH SRVRRAALRL LTYLSCRFGL ARVHWAFKFF DSQGARSRPS
    61  RVSDFRELGS RSWEDFEEEL EARLEDRAHL PGPAPRATHT HGALMETLLD YQWDRPEITS
   121  PTKPILRSSG RRLLDVESEA KEAEAALGGL VNAVFLLAPC PHSQRELLQF VSGCEAQAQR
   181  LPPTPKQVME KLLPKRVREV MVARKITFYW VDTTEWSKLW ESPDHLGYWT VCELLHHGGG
   241  TVLPSESFSW DFAQAGEMLL RSGIKLSSEP HLSPWISMLP TDATLNRLLY NSPEYEASFP
   301  RMEGMLFLPV EAGKEIQETW TVTLEPLAMH QRHFQKPVRI FLKGSVAQWS LPTSSTLGTD
   361  SWMLGSPEES TATQRLLFQQ LVSRLTAEEL HLVADVDPGE GRPPITGVIS PLSASAMILT
   421  VCRTKEAEFQ RHVLQTAVAD SPRDTASLFS DVVDSILNQT HDSLADTASA ASPVPEWAQQ
   481  ELGHTTPWSP AVVEKWFPFC NISGASSDLM ESFGLLQAAS ANKEESSKTE GELIHCLAEL
   541  YQRKSREEST IAHQEDSKKK RGVPRTPVRQ KMNTMCRSLK MLNVARLNVK AQKLHPDGSP
   601  DVAGEKGIQK IPSGRTVDKL EDRGRTLRSS KPKDFKTEEE LLSYIRENYQ KTVATGEIML
   661  YACARNMIST VKMFLKSKGT KELEVNCLNQ VKSSLLKTSK SLRQNLGKKL DKEDKVRECQ
   721  LQVFLRLEMC LQCPSINEST DDMEQVVEEV TDLLRMVCLT EDSAYLAEFL EEILRLYIDS
   781  IPKTLGNLYN SLGFVIPQKL AGVLPTDFFS DDSMTQENKS PLLSVPFLSS ARRSVSGSPE
   841  SDELQELRTR SAKKRRKNAL IRHKSIAEVS QNLRQIEIPK VSKRATKKEN SHPAPQQPSQ
   901  PVKDTVQEVT KVRRNLFNQE LLSPSKRSLK RGLPRSHSVS AVDGLEDKLD NFKKNKGYHK
   961  LLTKSVAETP VHKQISKRLL HRQIKGRSSD PGPDIGVVEE SPEKGDEISL RRSPRIKQLS
  1021  FSRTHSASFY SVSQPKSRSV QRVHSFQQDK SDQRENSPVQ SIRSPKSLLF GAMSEMISPS
  1081  EKGSARMKKR SRNTLDSEVP AAYQTPKKSH QKSLSFSKTT PRRISHTPQT PLYTPERLQK
  1141  SPAKMTPTKQ AAFKESLKDS SSPGHDSPLD SKITPQKRHT QAGEGTSLET KTPRTPKRQG
  1201  TQPPGFLPNC TWPHSVNSSP ESPSCPAPPT SSTAQPRREC LTPIRDPLRT PPRAAAFMGT
  1261  PQNQTHQQPH VLRAARAEEP AQKLKDKAIK TPKRPGNSTV TSSPPVTPKK LFTSPLCDVS
  1321  KKSPFRKSKI ECPSPGELDQ KEPQMSPSVA ASLSCPVPST PPELSQRATL DTVPPPPPSK
  1381  VGKRCRKTSD PRRSIVECQP DASATPGVGT ADSPAAPTDS RDDQKGLSLS PQSPPERRGY
  1441  PGPGLRSDWH ASSPLLITSD TEHVTLLSEA EHHGIGDLKS NVLSVEEGEG LRTADAEKSS
  1501  LSHPGIPPSP PSCGPGSPLM PSRDVHCTTD GRQCQASAQL DNLPASAWHS TDSASPQTYE
  1561  VELEMQASGL PKLRIKKIDP SSSLEAEPLS KEESSLGEES FLPALSMPRA SRSLSKPEPT
  1621  YVSPPCPRLS HSTPGKSRGQ TYICQACTPT HGPSSTPSPF QTDGVPWTPS PKHSGKTTPD
  1681  IIKDWPRRKR AVGCGAGSSS GRGEVGADLP GSLSLLESEG KDHGLELSIH RTPILEDFEL
  1741  EGVCQLPDQS PPRNSMPKAE EASSWGQFGL SSRKRVLLAK EEADRGAKRI CDLREDSEVS
  1801  KSKEGSPSWS AWQLPSTGDE EVFVSGSTPP PSCAVRSCLS ASALQALTQS PLLFQGKTPS
  1861  SQSKDPRDED VDVLPSTVED SPFSRAFSRR RPISRTYTRK KLMGTWLEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TICRR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

esophagus: 4 nTPM
thymus: 3.9 nTPM
bone marrow: 3.2 nTPM
tonsil: 1.7 nTPM
testis: 1.4 nTPM
lymph node: 1.3 nTPM

Single-cell type

monocyte progenitors: 35 nCPM
erythrocyte progenitors: 24 nCPM
megakaryocyte progenitors: 20 nCPM
esophageal basal cells: 16 nCPM
epicardial cells: 16 nCPM
early primary spermatocytes: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 1 nTPM
basal ganglia: 0.8 nTPM
medulla oblongata: 0.8 nTPM
spinal cord: 0.8 nTPM
amygdala: 0.7 nTPM
hypothalamus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: -1.45
DepMap mean gene effect: -1.78
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Treslin
Treslin, M domain
Treslin, N-terminal domain
Treslin, STD domain
Treslin, M domain
Treslin, N-terminal domain
Treslin, STD domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TICRR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TOPBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TICRR as an antibody target. Whether an autoantibody or antibody against TICRR could matter depends on whether native TICRR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TICRR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TICRR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...