Seroatlas · Human Serome Atlas

THSD1

Thrombospondin type-1 domain-containing protein 1

Also known as: THSD1_HUMAN, TMTSP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NS62
Gene
THSD1
Ensembl
ENSG00000136114
Chromosome
13
Canonical length
852 aa
Protein class
Disease related genes, Predicted membrane proteins
Subcellular location
Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q9NS62|THSD1
     1  MKPMLKDFSN LLLVVLCDYV LGEAEYLLLR EPGHVALSND TVYVDFQYFD GANGTLRNVS
    61  VLLLEANTNQ TVTTKYLLTN QSQGTLKFEC FYFKEAGDYW FTMTPEATDN STPFPWWEKS
   121  AFLKVEWPVF HVDLNRSAKA AEGTFQVGLF TSQPLCPFPV DKPNIVVDVI FTNSLPEARR
   181  NSRQPLEIRT SKRTELAQGQ WVEFGCAPLG PEAYVTVVLK LLGRDSVITS TGPIDLAQKF
   241  GYKLVMVPEL TCESGVEVTV LPPPCTFVQG VVTVFKEAPR YPGKRTIHLA ENSLPLGERR
   301  TIFNCTLFDM GKNKYCFDFG ISSRSHFSAK EECMLIQRNT ETWGLWQPWS QCSATCGDGV
   361  RERRRVCLTS FPSSPVCPGM SLEASLCSLE ECAAFQPSSP SPLQPQGPVK SNNIVTVTGI
   421  SLCLFIIIAT VLITLWRRFG RPAKCSTPAR HNSIHSPSFR KNSDEENICE LSEQRGSFSD
   481  GGDGPTGSPG DTGIPLTYRR SGPVPPEDDA SGSESFQSNA QKIIPPLFSY RLAQQQLKEM
   541  KKKGLTETTK VYHVSQSPLT DTAIDAAPSA PLDLESPEEA AANKFRIKSP FPEQPAVSAG
   601  ERPPSRLDLN VTQASCAISP SQTLIRKSQA RHVGSRGGPS ERSHARNAHF RRTASFHEAR
   661  QARPFRERSM STLTPRQAPA YSSRTRTCEQ AEDRFRPQSR GAHLFPEKLE HFQEASGTRG
   721  PLNPLPKSYT LGQPLRKPDL GDHQAGLVAG IERTEPHRAR RGPSPSHKSV SRKQSSPISP
   781  KDNYQRVSSL SPSQCRKDKC QSFPTHPEFA FYDNTSFGLT EAEQRMLDLP GYFGSNEEDE
   841  TTSTLSVEKL VI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • lung: 11 nTPM
  • placenta: 11 nTPM
  • tongue: 9.9 nTPM
  • adipose tissue: 9.6 nTPM
  • heart muscle: 8.8 nTPM
  • amygdala: 8.5 nTPM

Single-cell type

  • lymphatic endothelial cells: 75 nCPM
  • retinal ganglion cells: 46 nCPM
  • vascular endothelial cells: 43 nCPM
  • astrocytes: 42 nCPM
  • epididymal basal cells: 40 nCPM
  • fibro-adipogenic progenitors: 31 nCPM

Immune cell

  • NK-cell: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 11 nTPM
  • hippocampal formation: 10 nTPM
  • amygdala: 9.9 nTPM
  • basal ganglia: 8.7 nTPM
  • thalamus: 7 nTPM
  • white matter: 6.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about THSD1.

Disease | AllUniProt

Conditions THSD1 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 144 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THSD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THSD1 as an antibody target. Whether an autoantibody or antibody against THSD1 could matter depends on whether native THSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THSD1 is annotated at the cell surface, where native THSD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label THSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/THSD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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