Seroatlas · Human Serome Atlas

THRSP

Thyroid hormone-inducible hepatic protein

Also known as: Lpgp, LPGP1, S14, SPOT14, THRP, THRSP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92748
Gene: THRSP
Ensembl: ENSG00000151365
Chromosome: 11
Canonical length: 146 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>Q92748|THRSP
     1  MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ AEAPDLYTYF
    61  TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED ESASGELDLE AQFHLHFSSL
   121  HHILMHLTEK AQEVTRKYQE MTGQVW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THRSP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 412 nTPM

Expression across tissuesHPA

Tissue

liver: 412 nTPM
adipose tissue: 197 nTPM
breast: 92 nTPM
blood vessel: 47 nTPM
salivary gland: 46 nTPM
skin: 33 nTPM

Single-cell type

breast lactating cells: 134 nCPM
hepatocytes: 88 nCPM
epididymal clear cells: 80 nCPM
adipocytes: 43 nCPM
oocytes: 41 nCPM
breast secretory cells: 13 nCPM

Immune cell

NK-cell: 0.2 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 7.5 nTPM
pons: 2.7 nTPM
cerebral cortex: 2.3 nTPM
midbrain: 2.1 nTPM
basal ganglia: 1.9 nTPM
hippocampal formation: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THRSP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THRSP as an antibody target. Whether an autoantibody or antibody against THRSP could matter depends on whether native THRSP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THRSP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THRSP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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