TEX264
Testis-expressed protein 264
Also known as: FLJ13935, TX264_HUMAN, ZSIG11
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y6I9
- Gene
- TEX264
- Ensembl
- ENSG00000164081
- Chromosome
- 3
- Canonical length
- 313 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Endoplasmic reticulum
OverviewNCBI Gene
Enables signaling receptor activity. Involved in protein-DNA covalent cross-linking repair. Acts upstream of or within reticulophagy. Located in several cellular components, including autophagosome membrane; endoplasmic reticulum membrane; and replication fork. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
313 residues, UniProt reviewed canonical sequence.
>Q9Y6I9|TEX264
1 MSDLLLLGLI GGLTLLLLLT LLAFAGYSGL LAGVEVSAGS PPIRNVTVAY KFHMGLYGET
61 GRLFTESCSI SPKLRSIAVY YDNPHMVPPD KCRCAVGSIL SEGEESPSPE LIDLYQKFGF
121 KVFSFPAPSH VVTATFPYTT ILSIWLATRR VHPALDTYIK ERKLCAYPRL EIYQEDQIHF
181 MCPLARQGDF YVPEMKETEW KWRGLVEAID TQVDGTGADT MSDTSSVSLE VSPGSRETSA
241 ATLSPGASSR GWDDGDTRSE HSYSESGASG SSFEELDLEG EGPLGESRLD PGTEPLGTTK
301 WLWEPTAPEK GKELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TEX264 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 110 nTPM
Expression across tissuesHPA
Tissue
- testis: 110 nTPM
- parathyroid gland: 83 nTPM
- choroid plexus: 82 nTPM
- adrenal gland: 72 nTPM
- skin: 69 nTPM
- kidney: 67 nTPM
Single-cell type
- late primary spermatocytes: 359 nCPM
- early primary spermatocytes: 288 nCPM
- cytotrophoblasts: 172 nCPM
- esophageal apical cells: 162 nCPM
- breast lactating cells: 139 nCPM
- megakaryocytes: 130 nCPM
Immune cell
- T-reg: 160 nTPM
- total PBMC: 140 nTPM
- memory CD4 T-cell: 123 nTPM
- MAIT T-cell: 121 nTPM
- gdT-cell: 120 nTPM
- non-classical monocyte: 116 nTPM
Brain region
- choroid plexus: 49 nTPM
- cerebellum: 40 nTPM
- white matter: 38 nTPM
- hypothalamus: 37 nTPM
- medulla oblongata: 37 nTPM
- spinal cord: 35 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0.16
- gnomAD missense Z
- 0.51
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TEX264 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TEX264 as an antibody target. Whether an autoantibody or antibody against TEX264 could matter depends on whether native TEX264 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TEX264 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TEX264 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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