Seroatlas · Human Serome Atlas

TEX13A

Testis-expressed protein 13A

Also known as: TX13A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXU3
Gene: TEX13A
Ensembl: ENSG00000268629
Chromosome: X
Canonical length: 409 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is similar to a mouse gene that is expressed in the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

409 residues, UniProt reviewed canonical sequence.

>Q9BXU3|TEX13A
     1  MALRPEDPSS GFRHSNVVAF INEKMARHTK GPEFYLENIS LSWEKVEDKL RAILEDSEVP
    61  SEVKEACTWG SLALGVRFAH RQAQLQRHRV RWLHGFAKLH KSAAQALASD LKKLREQQET
   121  ERKEAASRLR MAQTSLVEVQ KERDKELVSP HEWEQGAGWP GLATAGGVCT EGAAEEEEEA
   181  AVAAAGAAGG KGAEEEQRDV EVVAAPVEAM APPVEAGAAP METQFPHVEA RAASMETTEK
   241  LERILLQLLG DADQEKYTYW GQKEGDLRSV ETATSYFSGT TNPWSRASSE PLPVQLPASY
   301  SYSYSSPFSS FSDIPTISPP QATVTAPVPP QLPSDWEAFD TSLWSDGGPH RIDHQEHPRD
   361  RRYSEPHQQR PPVYRRPGDW DCPWCNAVNF SRRDTCFDCG KGIWLQKPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX13A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 226 nCPM
early spermatids: 87 nCPM
late primary spermatocytes: 51 nCPM
early primary spermatocytes: 1.1 nCPM
undifferentiated spermatogonia: 0.5 nCPM
differentiating spermatogonia: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
pons: 0.1 nTPM
thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0.02
gnomAD missense Z: -0.82

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX13A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CNOT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX13A as an antibody target. Whether an autoantibody or antibody against TEX13A could matter depends on whether native TEX13A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX13A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEX13A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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