Seroatlas · Human Serome Atlas

TDRP

Testis development-related protein

Also known as: C8orf42, INM01, TDRP_HUMAN, TDRP1, TDRP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YL5
Gene: TDRP
Ensembl: ENSG00000180190
Chromosome: 8
Canonical length: 185 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Acts upstream of or within spermatogenesis. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

185 residues, UniProt reviewed canonical sequence.

>Q86YL5|TDRP
     1  MWKLGRGRVL LDEPPEEEDG LRGGPPPAAA AAAQAQVQGA SFRGWKEVTS LFNKDDEQHL
    61  LERCKSPKSK GTNLRLKEEL KAEKKSGFWD NLVLKQNIQS KKPDEIEGWE PPKLALEDIS
   121  ADPEDTVGGH PSWSGWEDDA KGSTKYTSLA SSANSSRWSL RAAGRLVSIR RQSKGHLTDS
   181  PEEAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

placenta: 34 nTPM
thyroid gland: 25 nTPM
kidney: 23 nTPM
ovary: 21 nTPM
basal ganglia: 19 nTPM
choroid plexus: 19 nTPM

Single-cell type

syncytiotrophoblasts: 506 nCPM
cytotrophoblasts: 261 nCPM
migrating cytotrophoblasts: 230 nCPM
choroid plexus epithelial cells: 169 nCPM
retinal pigment epithelial cells: 158 nCPM
salivary ionocytes: 140 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 37 nTPM
hypothalamus: 21 nTPM
medulla oblongata: 19 nTPM
midbrain: 17 nTPM
basal ganglia: 17 nTPM
pons: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -1.87
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

spermatogenesis

Cellular components

Protein domainsUniProt · Pfam · InterPro

Testis development-related protein
Testis development-related protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TDRP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRM2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRP as an antibody target. Whether an autoantibody or antibody against TDRP could matter depends on whether native TDRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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