Seroatlas · Human Serome Atlas

TCP11X2

T-complex protein 11-like X-linked protein 2

Also known as: T11X2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5H9J9
Gene
TCP11X2
Canonical length
502 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TCP11X2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

502 residues, UniProt reviewed canonical sequence.

>Q5H9J9|TCP11X2
     1  MPKTEETVLQ NDPSVAENGA PEPKTPGQSQ KSKSFCLDDQ SPDLIETVNE VSKLSISHEI
    61  VVNQDFYVEE TILPPNSVEG RFAEAMYNAF WNHLKEQLLS TPPDFTCALE LLKDVKETLL
   121  SLLLPWQNRL RNEIEEALDT DLLKQEAEHG ALDVPHLSNY ILNLMALLCA PVRDEAIQKL
   181  ETIRDPVQLL RGILRVLGLM KMDMVNYTIQ SFRPYLQEHS IQYEQAKFQE LLDKQPSLLD
   241  YTTKWLTKAA TDITTLCPSS PDSPSSSCSM ACSLPSGAGN NSEPPSPTMV LYQGYLNLLL
   301  WDLENVEFPE TLLMDRIRLQ ELAFQLHQLT VLASVLLVAR SFSGEVLFRS PEFVDRLKCT
   361  TKALTEEFIS RPEETMLSVS EQVSQEVHQG LKDMGLTTLS SENTASLLGQ LQNITKKENC
   421  IRSIVDQWIR FFLKCCLLHG MQESLLHFPG GLILIEKELA ELGWKFLNLM HHNQQVFGPY
   481  YAEILKHIIH PAQAQETDVE PN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCP11X2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 0.9 nTPM
  • fallopian tube: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • ependymal cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • spinal cord: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCP11X2 as an antibody target. Whether an autoantibody or antibody against TCP11X2 could matter depends on whether native TCP11X2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCP11X2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCP11X2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCP11X2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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